Colonic histoplasmosis in acquired immunodeficiency syndrome

Graham, Bruce D.; McKinsey, David S.; Driks, Michael R.; Smith, David

doi:10.1007/bf02049996

Cited by 20 publications

(3 citation statements)

References 26 publications

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“…8) (21,30,33,39). Patchy erythema, plaques, ulcerations, pseudopolyps, small (3-to 8-mm) nodules, thickened intestinal folds, luminal masses, and strictures may be seen at endoscopy; occasionally, these resemble cancer or inflammatory bowel disease (12,24,30). Omental and mesenteric nodules that cause peritonitis and ascites have been reported (1).…”

Section: Clinical Findingsmentioning

confidence: 99%

Endemic mycoses in AIDS: a clinical review

Wheat

1995

Clin Microbiol Rev

149

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Histoplasmosis and coccidioidomycosis are serious opportunistic infections in patients with AIDS who reside in areas of endemicity of the United States and Central and South America. Blastomycosis, although less common, also must be recognized as an opportunistic infection in patients with AIDS. Prompt diagnosis requires knowledge of the clinical syndromes and diagnostic tests as well as a high index of suspicion. Histoplasmosis and blastomycosis respond well to antifungal treatment, but relapse is common without chronic suppressive therapy. Improvements in treatment are needed in coccidioidomycosis. Research is needed to identify preventive strategies for patients at risk. These strategies may include use of prophylactic antifungal therapy or vaccination.

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Section: Clinical Findingsmentioning

confidence: 99%

Endemic mycoses in AIDS: a clinical review

Wheat

1995

Clin Microbiol Rev

149

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“…To our knowledge, histoplasmosis specifically affecting the colon has not been reported in a liver transplant recipient, although it has been described in other immunocompromised patient populations, including those with acquired immunodeficiency syndrome, Job's syndrome, and common variable immunodeficiency, or after renal transplantion 3–18…”

Section: Discussionmentioning

confidence: 97%

“…Immunosuppression has been shown to be a risk factor for dissemination 2. Although this mycosis has been well described in immunocompromised patients,3–18 disseminated histoplasmosis has rarely been reported in liver transplant patients.…”

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confidence: 99%

Disseminated histoplasmosis in a liver transplant recipient

Lisker‐Melman

Korenblat

et al. 2006

Liver Transpl

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A 61-yr-old liver transplant recipient presented with abdominal cramping and nonbloody diarrhea resulting in orthostasis. Multiple ulcerations throughout the colon were seen during endoscopy, and biopsies from the ulcer edges revealed histoplasmosis. Treatment with a course of itraconazole improved the diarrhea. The patient later presented with pericarditis and symptomatic pleural effusions, the latter of which was confirmed to be a result of disseminated histoplasmosis. Treatment with amphotericin B led to resolution. Histoplasmosis should be considered in liver transplant patients with diarrhea and large ulcers in the colon. The presence of disseminated histoplasmosis should be ruled out once colonic histoplasmosis has been diagnosed.

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Intestinal Perforation From Gastrointestinal Histoplasmosis in Acquired Immunodeficiency Syndrome

Heneghan

Li²,

Petrossian³

et al. 1993

Arch Surg

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Gastrointestinal involvement with histoplasmosis in patients with the acquired immunodeficiency syndrome is a rare but documented phenomenon. Most patients present with diarrhea, fever, and abdominal pain. We present a case of a woman who tested positive for the human immunodeficiency virus antibody who developed an intestinal perforation due to Histoplasma capsulatum of the ileum. The patient, whose only risk factor was a blood transfusion 8 years earlier, had been previously diagnosed as having disseminated histoplasmosis with gastrointestinal involvement. While receiving oral antifungal treatment (itraconazole), she developed two separate areas of ileal perforation due to H capsulatum. Complications from gastrointestinal involvement with histoplasmosis, such as perforation, should be considered in patients infected with the human immunodeficiency virus with signs and symptoms suggesting abdominal disease.

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Colonic histoplasmosis in acquired immunodeficiency syndrome

Cited by 20 publications

References 26 publications

Endemic mycoses in AIDS: a clinical review

Endemic mycoses in AIDS: a clinical review

Disseminated histoplasmosis in a liver transplant recipient

Intestinal Perforation From Gastrointestinal Histoplasmosis in Acquired Immunodeficiency Syndrome

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