Gastrointestinal histoplasmosis in the acquired immunodeficiency syndrome: report of 18 cases and literature review

Assi, Maha; McKinsey, David S.; Driks, Michael R.; O'Connor, Mary C.; Bonacini, Maurizio; Graham, Bruce D.; Manian, Farrin A.

doi:10.1016/j.diagmicrobio.2006.01.015

Cited by 79 publications

(85 citation statements)

References 22 publications

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“…The most important risk factors are immunosuppression, including transplantation, chronic renal disease, prolonged use of corticosteroids, acquired immune deficiency syndrome (AIDS) and age over 54 years-old 1,7 . In the last few years, AIDS has contributed to the increased incidence of DH, described in some series as up to 25% 1,6,8 .…”

Section: Introductionmentioning

confidence: 99%

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Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Antonello

Zaltron

Vial

et al. 2011

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: Histoplasmosis is a systemic mycosis endemic in Brazil, especially in the State of Rio Grande do Sul, where Histoplasma capsulatum was isolated from the soil. H. capsulatum may compromise unusual areas, including the oropharynx, particularly in patients presenting disseminated histoplasmosis; which is associated with a state of immunosuppression, such as AIDS. METHODS: During database analysis of a total of 265 cases of histoplasmosis, the medical records of 11 patients with histological or microbiological diagnoses of oral histoplasmosis (OH) between 1987 and 2008 were retrospectively reviewed. RESULTS: This work reports 11 cases of OH, the majority presenting histopathological or microbiological evidence of disseminated histoplasmosis (DH). In the patients with DH, OH was the first manifestation of histoplasmosis. Five of the 11 patients discussed were HIV-seropositive with clinical and laboratory findings of AIDS. Four patients presented active pulmonary tuberculosis concomitant with histoplasmosis. Treatment was based on the use of itraconazole and amphotericin B deoxycholate. Eight patients responded successfully to therapy after one year, two did not come back for reevaluation and one died despite adequate therapy. CONCLUSIONS: Oral histoplasmosis is closely associated with immunosuppression status, especially in patients presenting AIDS; moreover, in many cases, OH is the first sign of disseminated histoplasmosis.

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Section: Introductionmentioning

confidence: 99%

“…The most common sites of oral cavity affected are the tongue, palate and buccal mucosa 8 . The clinical significance of oropharyngeal lesions is primarily diagnostic.…”

Section: Introductionmentioning

confidence: 99%

Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Antonello

Zaltron

Vial

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…On endoscopy, these lesions may appear inflamed, thickened, ulcerated, stricture, polypoid or tumor-like. [5] However, in this case, the duodenum appeared endoscopically normal and biopsies were taken only as part of her iron deficiency evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…[6,7] GIH can be found anywhere along the GI tract, from mouth to anus, however the highest incidence is within the ileum and cecum. [5] It is suspected that the abundance of gutassociated lymphoid tissues, such as Peyer's patches in the terminal ileum, allow entry of infected macrophages. The duodenum is rarely involved, appreciated in less than 4% of cases, making it one of the rarest sites of GI involvement.…”

Section: Discussionmentioning

confidence: 99%

“…When present, nonspecific symptoms of GIH include fever, weight loss, abdominal pain, diarrhea, nausea, anorexia, vomiting, and constipation. [4,5] Gastrointestinal involvement in disseminated histoplasmosis is recognized in less than 10% of patients. At autopsy, however, it is seen in 70% of those with disseminated histoplasmosis, suggesting GIH has a higher prevalence than is clinically recognized.…”

Section: Discussionmentioning

confidence: 99%

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Disseminated histoplasmosis diagnosed on routine outpatient endoscopy in a renal transplant patient

Luu

Benson

Schwake

2018

CRIM

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A 58-year-old female with prior renal transplant on immunosuppression underwent upper endoscopy and colonoscopy to evaluate iron deficiency anemia. Her upper endoscopy appeared normal and her colonoscopy showed mild colitis in her transverse colon. Biopsies of her duodenum, taken to evaluate for celiac disease, as well as biopsies of the colitis showed intracellular yeast within histiocytes in the lamina propria consistent with disseminated histoplasmosis. This case describes a renal transplant patient with disseminated gastrointestinal histoplasmosis (GIH), which is rarely diagnosed on routine outpatient endoscopy.

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Treating progressive disseminated histoplasmosis in people living with HIV

Murray

Hine

2020

Cochrane Database of Systematic Reviews

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Gastrointestinal histoplasmosis in the acquired immunodeficiency syndrome: report of 18 cases and literature review

Cited by 79 publications

References 22 publications

Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Disseminated histoplasmosis diagnosed on routine outpatient endoscopy in a renal transplant patient

Treating progressive disseminated histoplasmosis in people living with HIV

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