We propose that the oxidative stress response induced by the dengue virus may trigger the inflammatory cytokine responses in dengue severity and thereby contributes to the pathogenesis of the disease; however the interplay between the oxidative response and inflammatory activity in disease virulence needs further study.

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Organophosphorus compounds (OPCs) are common pesticides used in agriculture in India. In this study, totally 24 patients had hypokalemia. Of 39 male patients,20 patients (51.3%) had hypokalemia. Of 11 female patients, 4 patients(36.4%)had hypokalemia. Of 50 patients totally, 14 had hyponatremia(<135 meq/dl) which constitutes 28%. Of this 6 patients had hypokalemia which accounts for 42.9%of hyponatremia.Of 24 patients with hypokalemia this 6 cases of hyponatremia accounts for 25%. Hypokalemia increases both morbidity and mortality in organophosphorus compound poisoning significantly.Hypokalemia can be used as a reliable and a cost effective marker of morbidity and mortality in organophosphorus compound poisoning

Early diagnosis and treatment are crucial in the management of pancytopenia. A retrospective cross-sectional study was undertaken at ZMCH,DAHOD. All eligible participants more than 13 years of age were included. A thorough history taking along with clinical examination and laboratory investigations were performed among the study population. Data was analyzed using SPSS version 13. The most common nding suggestive of etiology was megaloblastic anemia at 38.4%, which was more common among females. Aplastic anemia was the second most common nding at 24.6%. Other diagnoses included hypersplenism, myelodysplastic syndrome and acute leukemia. Fever and pallor were the most common presenting symptoms. Blood examinations demonstrated anisopoikilocytosis, hypersegmented neutrophils, erythroblasts, macrocytes and reticulocytes, which were found in differing proportions in the various etiological diagnoses.It is noteworthy that megaloblastic anemia, a reversible condition, is common in India compared to the higher occurrence of aplastic anemia and myelodysplastic syndrome in developed nations

Liver involvement in dengue fever is manifested by the elevation of transaminases due to direct attack of virus itself or the use of hepatotoxic drugs.Objective of our study was to assess the serum aminotransferase level in patient with dengue fever and to correlate serum aminotransferase level and severity of dengue fever. This is a prospective observational study. Atotal of 50 fever patients admitted with positive dengue serology in Medicial ward, ZMCH ,Dahod,were included after satisfying the inclusion and exclusion criteria. All the patients were subjected to complete history taking and clinical examination. Investigations like complete blood count, liver function test, dengue serology and abdominal ultrasound were done in all patients.A total of 50 dengue serology positive patient were included in the study. Among them there were 27 (54%) males and 24(46%) females. In our study 41 patients (82%) had elevated serum transaminase level, Mean ASTlevel was 134.84 IU/Land the mean ALTlevel was 107.88 IU/L. The level of AST is higher when compared to ALT in most of the patients. Among those who had elevated aminotransferase level 12 patients (24%) had both elevated aminotransferase level and free uid in the abdomen. Out of 50 patients 32 (64%) had reduced platelet count (less than one lakh) and all the 32 patients had elevated serum aminotransferase level. There was signicant negative correlation between serum aminotransferase level and platelet count (P value < 0.001).Hepatic dysfunction is very common in all forms of Dengue infection. Serum Aminotransferase level correlate with severity of Dengue fever. Aspartate Aminotransferase was signicantly raised when compared to Alanine Aminotransferase in most of the patients