The aim of this study was to improve the dissolution rate of the poorly soluble drug Clofibrate by delivering the drug as a liquisolid compact. Liquisolid compacts were prepared using propylene glycol as solvent, microcrystalline cellulose as carrier, Starch, Silica and Lactose are used as coating materials. Sodium starch glycolate and Cross carmellose sodium are used as a Super disintigrants. The crystallinity of the newly formulated drug and the interaction between excipients was examined by X-ray powder diffraction and Fouriertransform infrared spectroscopy, respectively. The dissolution studies for the liquisolid formulation and the Conventional tablet were carried out at a pH 6.8 buffer. The results showed no change in the crystallinity of the drug and no interaction between excipients. The dissolution efficiency of Clofibrate at 60 min was increased from 71.02% for plain drug and 81.3% for Conventional Tablet to 100.47% for the liquisolid formulation. The increase in the dissolution rate was also found to be significant compared to the pure drug and Conventional Tablet at pH 6.8 buffer. The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like Clofibrate.
Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of medication in the remaining tissues. Thus improving efficacy of the drug and reducing side effects. The nasal mucosa when compared to other mucous membranes is easily accessible and provides a practical entrance portal for small and large molecules. Intranasal administration offers rapid onset of action, no first-pass effect, no gastrointestinal degradation or lung toxicity and non-invasiveness application and also improves bioavailability. It is thought that olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field.
Oral Disintegrating Tablets (ODTs) may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first-pass hepatic metabolism and potentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The objectives of the research work was to formulate oral disintegrating tablets of Atenolol maleate by using different super disintegrates (Natural, Synthetic) in different ratio by direct compression technique and tablets were evaluated for pre compression and post compression parameters such as angle of repose, bulk density, tapped density, compressibility index, drug content and in-vitro drug release study, hardness, friability, wetting time and in vitro dispersion time. Among the all formulations, the promising formula (CCS3, IH2) have showed fast disintegration and displayed in vitro dispersion time of 11 s and 10.5 s. The dissolution rates of the optimized formulations (CCS3, IH2) were found to be good. Among the promising ODT formulation CCS3, IH2 the formula IH2 was found to be superior when compared to formulation CCS3 since formulation IH2 used natural disintegrant (i.e. 6 %w/w Isphagula husk) at a lower concentration than the formulation CCS3 (8 % w/w Cross Carmellose Sodium) hence it was found to be more cost effective. The FTIR studies also showed that there was no interaction between drug and polymer. Formulation CCS3, IH2 were subjected to stability studies as per ICH guidelines at temperatures and humidity of 25 ± 5ºC/60 ± 5 % RH; and 40 ± 5ºC/75 ± 5 % RH. Tablets didn't reveal any appreciable changes with respect to hardness, disintegration time, drug content and dissolution profile.
The objective of the present study was to prepare nanofibers of Lornoxicam by Electro spinning technique and to increase the drug bioavailability using different polymers such as PMMA, Ethyl Cellulose, Polyethylene oxide, Gelatin. Totally 15 different formulations of Lornoxicam were prepared by Electro spinning technique and prepared nanofibers are evaluated for various characteristics like drug content, in-vitro release studies, DSC, XRD and SEM studies. The dissolution profile of optimized formulation was compared with that of the API and the marketed product (Lofecam) and the Optimized formulation (F15) exhibited similar dissolution profiles as that of innovator brand. The drug release from the optimized formulation (F15) was slow and extended over a period of 8hrs and these nanofibers were found to be suitable for the oral controlled release formulation. The Optimized formulation (F15) followed First-order release kinetics as it showed highest linearity (r 2 =0.952).
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