Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of medication in the remaining tissues. Thus improving efficacy of the drug and reducing side effects. The nasal mucosa when compared to other mucous membranes is easily accessible and provides a practical entrance portal for small and large molecules. Intranasal administration offers rapid onset of action, no first-pass effect, no gastrointestinal degradation or lung toxicity and non-invasiveness application and also improves bioavailability. It is thought that olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field.
Crohn's disease is a type of inflammatory bowel disease (IBD) that frequently affects the ileo-cecal region. For effective treatment, a site-targeting delivery system in the ileo-cecal region is essential. Ciprofloxacin, a broad spectrum antibiotic is widely used for the treatment of Crohn's disease. The present study is an attempt to develop enteric coated polysaccharide beads which targets the drug to the colon. Polysaccharide beads were prepared using different polymers like sodium alginate, gellan gum and chitosan by dispersing the drug loaded solution into calcium chloride and sodium tripolyphosphate solution respectively. The prepared beads were then coated with Eudragit S 100 using pan coating method. Characterization done using SEM revealed that, eudragit coated beads had uniform surface texture. Swelling study suggested that, alginate beads alone or in combination with gellan gum showed good swelling behavior in phosphate buffer (pH 7.4), whereas chitosan beads showed better swelling in pH 1.2. The drug release showed up to 10 % in acidic environment and sustained under neutral condition for a period of 10 h. Release kinetics indicated non-Fickian transport controlled by diffusion and relaxation of the polymer. In-vivo studies in rabbits indicated that the formulation was targeted to the colon region.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.