Formulation and Evaluation of Orodispersible Atenolol Maleate Tablets: A Comparative Study on Natural Super Disintegrents and Synthetic Super Disintegrents

Abstract

Oral Disintegrating Tablets (ODTs) may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first-pass hepatic metabolism and potentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The objectives of the research work was to formulate oral disintegrating tablets of Atenolol maleate by using different super disintegrates (Natural, Synthetic) in different ratio by direct compression technique and tablets were evaluated for pre compression and post compression parameters such as angle of repose, bulk density, tapped density, compressibility index, drug content and in-vitro drug release study, hardness, friability, wetting time and in vitro dispersion time. Among the all formulations, the promising formula (CCS3, IH2) have showed fast disintegration and displayed in vitro dispersion time of 11 s and 10.5 s. The dissolution rates of the optimized formulations (CCS3, IH2) were found to be good. Among the promising ODT formulation CCS3, IH2 the formula IH2 was found to be superior when compared to formulation CCS3 since formulation IH2 used natural disintegrant (i.e. 6 %w/w Isphagula husk) at a lower concentration than the formulation CCS3 (8 % w/w Cross Carmellose Sodium) hence it was found to be more cost effective. The FTIR studies also showed that there was no interaction between drug and polymer. Formulation CCS3, IH2 were subjected to stability studies as per ICH guidelines at temperatures and humidity of 25 ± 5ºC/60 ± 5 % RH; and 40 ± 5ºC/75 ± 5 % RH. Tablets didn't reveal any appreciable changes with respect to hardness, disintegration time, drug content and dissolution profile.

Fast dissolving tablets: Opportunity in herbal drug delivery system

“…Spray drying is common in the pharmaceutical and biochemical industries, and the final size of the particles can be controlled by a number of variables, such as the size of the nozzle utilized during the procedure. [16] Figure 3 Spray drying Technique…”

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“…Aliquots of samples are withdrawn at regular intervals of time and volume withdrawn is replaced with fresh medium. Samples taken are then analyzed by using UV spectrophotometer or any other suitable technique 31 .…”

Formulation and Evaluation of Quinapril Sustained Release Matrix Tablets

“…Individual tablets were then weighed and compared with average weight. [20] Drug content uniformity [18][19][20] The drug content uniformity was determined by taking the powder equivalent to 10mg, then it was (n=3) dissolved in P H 6.8 phosphate. Required dilution (10µg/ml) was prepared and absorbance was taken against the blank at 246nm.…”

“…Dissolution studies [18][19][20] The tablet samples were subjected to In-vitro dissolution studies using USP Type II dissolution apparatus at 37±0.5°C and 50rpm speed. …”