Self-compacting concrete (SCC) is a type of concrete that is placed in the formwork under its own weight. Although there are many studies showing the behavior of SCC beams, most relate to the behavior of simple supported beams. Unlike those, this is a study of continuous beams made of SCC aimed to analyze their flexural performance as well as to confirm the possibility of using nonlinear finite element analysis (FEA) in the design of such structural elements. An experimental study of three two-span continuous beams of a total length of 3400 mm, with the span between supports of 1600 mm, with 150/200 mm cross section made of SCC exposed to short-term loading, was carried out. The parameter that varied is the percentage of tensile reinforcement, with values of 0.65, 0.86 and 0.94 being selected. As all analyzed beams have shown a satisfactory load-bearing capacity and stiffness, the research confirmed the possibility of using SCC in continuous beams in civil engineering practice. Using Abaqus/Standard software, a nonlinear numerical model is proposed, which is validated and verified against experimental research, as there is only a 5% difference in the numerically calculated ultimate load compared to the experimentally measured values.

Acute pancreatitis (AP) is an abrupt, variable inflammatory condition of the pancreas, potentially escalating to severe systemic inflammation, rampant pancreatic necrosis, and multi-organ failure. Its complex pathogenesis involves an intricate immune response, with different T cell subsets (Th1, Th2, Th9, Th17, Th22, TFH, Treg, and CD8+ T cells) and B cells playing pivotal roles. Early T cell activation initiates the AP development, triggering cytokines associated with the Th1 response, which stimulate macrophages and neutrophils. Other T cell phenotypes contribute to AP’s pathogenesis, and the balance between pro-inflammatory and anti-inflammatory cytokines influences its progression. Regulatory T and B cells are crucial for moderating the inflammatory response and promoting immune tolerance. B cells further contribute through antibody production, antigen presentation, and cytokine secretion. Understanding these immune cells’ roles in AP could aid in developing new immunotherapies to enhance patient outcomes. However, further research is required to define these cells’ precise roles in AP and their potential as therapeutic targets.

Introduction/Objective Pain, stiffness and limited mobility are the main factors that lead to difficulties in performing daily activities and are also responsible for the decline in the quality of life in people with knee osteoarthritis (OA). The aim of this study was to evaluate the functional capacity and health related quality of life (HRQoL) compared to pain in patients with knee OA, as well as to determine the correlation between these three clinical variables. Methods The study involved 931 patients diagnosed with knee OA. In all patients, pain was evaluated by a short form of the McGill pain questionnaire (SF-MPQ), functional status was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC), while life quality was evaluated using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Results The average age of patients was 61.21 ± 4.62 years, while 71.3% of them were women. The quality of life in patients with knee OA and all pain parameters contained in the SF-MPQ were highly statistically positively associated (p ≤ 0.01). In addition, the physical functioning was mostly affected by emotional pain (rho =-0.585). A high statistical correlation (p ≤ 0.01) was noted between stiffness and physical functioning from the WOMAC questionnaire and all of the parameters from the SF-MPQ. The physical functioning from the WOMAC questionnaire had the strongest correlation with total pain incorporated into the McGill questionnaire (rho = 0.530). Conclusion Knee pain has a significant impact on functional capacity and HRQoL in patients with knee OA. Therefore, one of the main therapy goals for OA of the knee should be to reduce the pain in the affected knee, which can help to improve the functionality and HRQoL of these patients.

Strengthening of concrete structures is applied as a solution for various deterioration problems in civil engineering practice. This also refers to the structures made of self-compacting concrete (SCC), which is increasingly in use, but there is a lack of research in this field. This paper presents an experimental analysis of flexural behavior of reinforced concrete (RC) continuous beams made of SCC, strengthened with fiber reinforced polymer (FRP) materials (glass (GFRP) and carbon (CFRP) bars, CFRP laminates), by the use of near surface mounted (NSM) and externally bonded (EB) methods. Six two-span continuous beams of a total length of 3200 mm, with the span between supports of 1500 mm and 120/200 mm cross section, were subjected to short-term load and tested. The displacements of beams and the strains in concrete, steel reinforcement, FRP bars and tapes were recorded until failure under a monotonically increasing load. The ultimate load capacities of the strengthened beams were enhanced by 22% to 82% compared to the unstrengthened control beam. The ductility of beams strengthened with GFRP bars was satisfactory, while the ductility of beams strengthened with CFRP bars and tapes was very small, so the failure modes of these beams were brittle.

The paper presents the procedure of limit load calculation of elasto-plastic trusses exposed to the action of proportional load which is gradually increased until the formation of failure mechanism. The calculation is based on the application of static and kinematic theorem of limit analysis which are the basis of the limit analysis of structures which produce the value of the limit load in a quick and efficient manner. Application of these theorems is displayed on the examples of truss girders loaded by one- and twoparameter load