BackgroundLimited information is available about the involvement of human papillomavirus (HPV) in head and neck squamous cell carcinomas (HNSCCs) in Romanian patients.ObjectiveTo evaluate the HPV-attributable fraction in HNSCCs collected in Northeastern Romania.Materials and methodsIn total, 189 formalin-fixed paraffin-embedded tissue samples (99 oral cavity tumors, 28 oropharynx, 48 pharynx, and 14 larynx/hypopharynx) were analyzed for HPV DNA and RNA using Luminex-based assays, and for overexpression of p16INK4a (p16) by immunohistochemistry.ResultsOf the 189 cases, 23 (12.2%) were HPV DNA-positive, comprising half of the oropharyngeal cases (14/28, 50.0%) and 9/161 (5.6%) of the non-oropharyngeal cases. HPV16 was the most prevalent HPV type (20/23, 86.9%), followed by HPV18 (5/23, 21.7%) and HPV39 (1/23, 4.3%). Only two (2/189, 1.1%) HNSCC cases were HPV-driven, i.e. positive for both HPV DNA and RNA.ConclusionA very small subset of HNSCC cases within this cohort from Northeastern Romania appeared to be HPV-driven.
In this paper, we propose an analyzis method for the dynamics of polymer chains, based on a Ricatti procedure induced by possible correlations through the compatibility of the thermal radiation-classical damped oscillator dynamics. Then, the quantification (radiation frecquency is directly proportional to the color temperature) and the erasure of one bit of information becomes a natural processes induced by the system structure itself. The theory has implications in the dynamics of biological structures (arhitecture of tumors, information on tumor growth and angiogenesis, etc.) in the form of Resonant Recognition Model.
Three-dimensional printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. Nowadays, 3D printing is very well integrated in the surgical practice and research. Also, the field of head and neck reconstructive surgery is constantly evolving because of the three-dimensional printing, a technology which can be widely used in a variety of situations such as reconstruction of tissue defects, surgical planning, medical modeling and prosthesis. By using 3D printing into tissue engineering and materials, it may be possible for otolaryngologists to implant 3D printed functional grafts into patients and will also provide a rapid production of personalized patient-specific devices. Advances in 3D printed implants and future tissue-engineered constructs will bring great progress to the field of otorhinolaryngology.
The retromolar-oropharynx junction cancer is a rare malignancy situated at the border between the oral cavity and the oropharynx. There is an important number of factors involved in the ethiology, pathogenesis and evolution of patients with this kind of lesions. We performed a prospective study involving 50 patients with this type of cancer, hospitalized between 2013-2015 in the Otorhinolaryngology and Maxillofacial Departments of the "Sf. Spiridon" Emergency Hospital, Iasi, Romania, to identify the environmental and biologic factors that may be involved in the damaged tissues. The purpose of our study is to appraise and validate the significance of the risk factors involved in the occurrence of deglutition and swallowing troubles, to achieve a treatment protocol for this kind of patients.
Noise is considered as an "unpleasant sound". Since ancient times noise was perceived like a disruptive element. In the last three centuries, particularly in industrialized countries, the noise became a major public health issue, especially for the hearing system. The harmful effects of noise are felt not only by the hearing system, but also by other systems (cardiovascular, central nervous system by affecting sleep and cognition) and it was recently pinpointed that the immune system and the fetus are affected. Studies conducted in several large cities from Romania, starting with the year 2000 show that a significant percent of population living in urban areas is exposed to over 55 dB noise during the day and above 50dB at night, the situation being identical with the one existing in other EU countries. There are more than two decades since the EU has been working on developing a harmonized noise policy. Until 2020, the EU policy's main objective is to ensure that "noise pollution in the Union will significantly decrease, moving closer to WHO-recommended levels".
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