Environmental Factors Involved in Genesis of Retromolar - Oropharynx Junction Cancer

Cobzeanu, Bogdan Mihail; Costan, Victor Vlad; Danciu, Mihai; Pasca, Sorin Aurelian; Sulea, Daniela; Ungureanu, Loredana; Moscalu, Mihaela; Cobzeanu, Mihail Dan; Popescu, Eugenia

doi:10.30638/eemj.2017.113

Cited by 7 publications

(6 citation statements)

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“…The frequency of HPV(+) cases (various strains: HPV16, 18, 31, 33, 51, 66) was found in 32% of cases ( Table 1 ). These tumor markers can significantly influence the evolution and staging of the tumor, and thus influence the therapeutic plan for each case [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

Predictive Value of HPV, p53, and p16 in the Post-Treatment Evolution of Malignant Tumors of the Oropharynx and Retromolar Trigone–Oropharynx Junction

Cobzeanu

Moscalu

et al. 2020

Medicina

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Background and objectives: Knowledge of the interactions and influences of infectious, genetic, and environmental factors on the evolution and treatment response of malignant tumors is essential for improving the management of the disease and increasing patient survival. The objective of this study was to establish the contribution of human papillomavirus (HPV), as well as p53 and p16 tumor markers, alongside associated factors (smoking and alcohol consumption), in the progression of malignancies located in the oropharynx and at the retromolar trigone–oropharyngeal junction. Materials and Methods: We performed a prospective study including 50 patients with malignant tumors of the oropharynx and retromolar trigone–oropharyngeal junction. In all patients, the presence and type of HPV were determined, as well as the status of the tumor markers p53 and p16. The associated risk factors, biopsy results, treatment method, and post-treatment evolution were all documented. Statistical analyses were performed to evaluate the correlations between the determining factors and their influence on the post-treatment evolution. An overall increased survival rate was found in HPV(+) patients. Results: Our study outlined the prevalence of different high-risk subtypes of HPV from the ones presented by other studies, suggesting a possible geographic variation. Correlations between the p53 and p16 statuses and patient survival could be established. The association of smoking and alcohol consumption strongly correlated with an unfavorable evolution. Conclusions: Awareness of the differences in the post-treatment evolution of the patients in relation to the presence of the factors determined in our study could change the future management of such cases for ensuring improved treatment outcomes.

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Section: Resultsmentioning

confidence: 99%

Predictive Value of HPV, p53, and p16 in the Post-Treatment Evolution of Malignant Tumors of the Oropharynx and Retromolar Trigone–Oropharynx Junction

Cobzeanu

Moscalu

et al. 2020

Medicina

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“…Several periodontal bacteria together with microbial proteases such as metalloproteases including host-derived MMPs, all participate in the process leading to progression of periodontitis, tissue, and ligament degradation. Among them are Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia; together with the host's genetics and other environmental factors, these bacteria are active contributors in the infections and inflammatory processes that result in the production of metalloproteases, including host MMPs [16,30,31]. MMP-9 is among the best studied proteinases when it comes to its role in periodontitis and its activation in infections.…”

Section: Discussionmentioning

confidence: 99%

Using Salivary MMP-9 to Successfully Quantify Periodontal Inflammation during Orthodontic Treatment

Luchian

Moscalu

Goriuc

et al. 2021

JCM

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Periodontitis is one of the most common immune-mediated inflammatory conditions resulting in progressive destruction of periodontium. Metalloproteinase-9 (MMP-9), an enzyme that is involved in the degradation of gelatin and collagen and present in the gingival crevicular fluid, is markedly increased in periodontitis. The aim of the study is to evaluate the effects of periodontal treatment either alone or in combination with orthodontic treatment on MMP-9 levels. In this study, 60 individuals were subjected to periodontal treatment (PD) or periodontal treatment combined with orthodontic treatment (POD). Both periodontal and periodontal plus orthodontic treatments significantly improved clinical parameters and lowered MMP-9 levels compared to control group. However, the combination of periodontal with orthodontic treatment further improved clinical parameters and enhanced the lowering effect on MMP-9 levels compared to periodontal or control groups alone. Finally, the degree of malocclusion significantly affected the effect of the treatment on MPP-9 levels with PD treatment having the most pronounced effect. We concluded that salivary MMP-9 can serve to accurately predict the level of inflammation in affected periodontal tissues during orthodontic treatment that is also associated with the type of malocclusion, making it a viable diagnosis tool in monitoring the progression of the periodontium during orthodontic treatment.

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“…At the same time, in our opinion, the present mathematical model confirms and explains the apparent paradoxes from clinical studies. Furthermore, our model can be used to analyze biological dynamics at nanoscale [35], with implications in various molecular medicine fields [36,37].…”

Section: Discussionmentioning

confidence: 99%

On the Chameleonic Behaviour of Cholesterol through a Fractal/Multifractal Model

Tesloianu¹,

Ghizdovăţ

Agop

et al. 2020

Computational and Mathematical Methods in Medicine

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An increasing number of studies are beginning to show that both low-density lipoprotein and high-density lipoprotein cholesterol can constitute risk factors for myocardial infarction. Such a behaviour has been called by experts in the field the “chameleonic effect” of cholesterol. In the present paper, a fractal/multifractal model for low-density lipoprotein and high-density lipoprotein cholesterol dynamics is proposed. In such a context, a fractal/multifractal tunneling effect for systems with spontaneous symmetry breaking is analyzed so that if the spontaneous symmetry breaking is assimilated to an inflammation (in the form of a specific scalar potential), then a coupling between two fractal/multifractal states can be observed. These two states, which have been associated to biological structures such as low-density lipoprotein and high-density lipoprotein, transfer their states through a fractal/multifractal tunneling effect. Moreover, in our opinion, the widely used notions of “good” and “bad” cholesterol must be redefined as two different states (low-density lipoprotein and high-density lipoprotein) of the same biological structure named “cholesterol.” In our work, for the first time in the specialized literature, low-density lipoprotein and high-density lipoprotein have been regarded as two different states of the same biological structure (named “cholesterol”), such as in nuclear physics, the neutron and proton are two different states of the same particle named nucleon.

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Environmental Factors Involved in Genesis of Retromolar - Oropharynx Junction Cancer

Cited by 7 publications

References 0 publications

Predictive Value of HPV, p53, and p16 in the Post-Treatment Evolution of Malignant Tumors of the Oropharynx and Retromolar Trigone–Oropharynx Junction

Predictive Value of HPV, p53, and p16 in the Post-Treatment Evolution of Malignant Tumors of the Oropharynx and Retromolar Trigone–Oropharynx Junction

Using Salivary MMP-9 to Successfully Quantify Periodontal Inflammation during Orthodontic Treatment

On the Chameleonic Behaviour of Cholesterol through a Fractal/Multifractal Model

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