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one (3) were isolated from the whole plants of Thalictrum glandulosissimum.Their structures were elucidated by spectroscopic methods, including extensive 1 H, 13 C, and 2D-NMR techniques. Compounds 1-3 were also tested for their anti-rotavirus activity. Compounds 1-3 exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 17.6, 15.0, and 23.6 respectively.The genus Thalictrum belongs to the subfamily Thalictroideae of Ranunculaceae and consists of the subgenera Thalictrum and Lecoyerium. 1,2 This genus has around 200 species, which are distributed in Asia, Europe, Africa, North America, and South America. Around 67 species are recorded in the flora of China, and the majority of which are found in Southwest China. At least 43 species of this genus are used medicinally in China. 2,3 This genus is also well known for its diverse pharmacological activities, including anti-tumor, anti-virus, anti-microbial, anti-tuberculosis, anti-inflammatory, anti-malarial activities, and the like, 4 and the main active ingredients found in this genus are alkaloids, 5-7 flavonoids, 8,9 triterpenoid saponins, 10,11 lithospermoside, 12 and the like.Thalictrum glandulosissimum is a herbaceous plant of Thalictrum genus with short rhizome and many thick fibrous roots. It distributed in Dali, Heqing, and Binchuan Prefecture, Yunnan Province, and grows on the hillside grassland at an altitude of 2500 meters. 2 The whole plants of T. glandulosissimum are used to treat some diseases, such as enteritis, dysentery, jaundice and throat by Bai nationality people in Yunnan Province of China, and the alkaloids are the main active components in this plants. 3,7,13,14 In the

Three new chromeno [3,2-c]pyridines (1-3) were isolated from the whole plants of Thalictrum scabrifolium. Their structures were elucidated by spectroscopic methods, including extensive 1 H, 13 C, and 2D-NMR techniques.Compounds 1-3 were also tested for their anti-rotavirus activity, and they exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 23.7, 18.3, and 19.2 respectively.The genus Thalictrum, a member of the Ranunculaceae family, comprises about 200 species widespread in temperate regions, 1,2 and around 67 species are recorded in the flora of China, 2 of which about 43 species have been used as traditional folk medicines to treat influenza, esoenteritis, cancer, dysentery, measles, and conjunctivitis. 3,4 Recent phytochemical and pharmacological investigations of Thalictrum plants uncovered that alkaloids are the main active components, 4-12 and many alkaloids with new efficacies have been isolated from the plants of this genus.Thalictrum scabrifolium var. leve is a perennial herb with stem height of 25 -40 cm. It is mainly distributed in Yulong, Jianchuan, and Heqing County, Yunnan Province, and grows on the hillside grassland at an altitude of 1900 -2500 meters. 2 The whole plants of T. scabrifolium are used as substitutes for Rhizoma coptidis to treat enteritis, dysentery, nephritis, and the inflamme of the mouth and throat. 13 Since the use of traditional medicinal plants has been practiced for centuries and tested by a huge number of patients, the ethnopharmacologic information of Thalictrum plants can contribute greatly to the development of new drugs.The chromenopyridine scaffold was regarded as the fusion of two main fragments (a chromene and a pyridine moiety). 14 Because both of the fragments display a wide range of biological activities, they

Three new quinoline alkaloids, thalicalkaloids A-C (1-3) together with three known alkaloids were isolated from the whole plant of Thalictrum atriplex.Their structures were elucidated by spectroscopic methods, including extensive 1 H, 13 C, and 2D-NMR techniques. Compounds 1-6 were tested for their antibacterial and anti-rotavirus activities. The results revealed that compound 3 exhibited high anti-rotavirus activity with therapeutic index (TI) valves of 24.0, and this valve is close to this positive control. Compounds 1, 2, 4-6 also showed potent anti-rotavirus activities with therapeutic index (TI) valves in the range of 11.0~15.8, respectively. In addition, compounds 1-6 showed good antimethicillin-resistant Staphylococcus aureus (anti-MRSA) activities with IZD of 12.2±1.5, 15.8±1.4, 14.5±1.2, 12.6±1.2, 13.4±1.4, and 14.0±1.5 mm, respectively.The genus Thalictrum comprises about 200 species, 1,2 and around 67 species had been recorded in the flora of China, 2 of which about 43 species have been used as traditional folk medicines. 3,4 The previous studies on the chemical constituents have indicated that the plants of this genus are a rich resource of alkaloids, and most of which possess many kinds of biological activities. [4][5][6][7][8][9][10][11][12] Thalictrum atriplex commonly called 'Ma Wei Lian' or 'Shui Huang Lian', is a traditional herbal medicine, and mainly distributes in Tibet, Sichuan and Yunnan provinces, and this plant had been used for the treatment of infectious hepatitis, carbuncles, dysenteric diarrhea and certain gastroenteric disorders in China. 13 Modern medicinal chemistry investigations also revealed that alkaloids, triterpenoids, flavonoids and the like, are the main constituents of the plant.

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