Vertically stacked van der Waals (vdW) heterojunctions based on two-dimensional (2D) transition metal dichalcogenides (TMDs) have attracted a great deal of attention and have created a powerful new material platform for novel, high-performance electronic and optoelectronic devices. Here, we report the construction of multilayer p-MoTe/n-MoS vdW heterostructures with remarkable rectification behavior, self-powered photoresponse and distinct photosensitivity at different laser wavelengths and power densities. Field effect transistors (FETs) fabricated by MoTe/MoS heterojunctions exhibit excellent gate-tunable rectification behavior and p-n junction transport characteristics, with the n-type dominating. The MoTe/MoS heterojunction devices generate a self-powered photocurrent at zero bias voltage with a considerable on-off ratio reaching ∼780 and achieve a stable and fast photoresponse, due to the type-II band alignment facilitating efficient electron-hole separation. Utilizing the advantages of a p-n junction with type-II band alignment, this MoTe/MoS vdW heterostructure provides more opportunities for future electronic and optoelectronic applications.

Background: The emerging Building Information Modelling (BIM) in the Architectural, Engineering and Construction (AEC)/Facility Management (FM) industry promotes life cycle process and collaborative way of working. Currently, many efforts have been contributed for professional integrated design/construction/maintenance process, there are very few practical methods that can enable a professional designer to effectively interact and collaborate with end-users/clients on a functional level. Method: This paper tries to address the issue via the utilisation of computer game software combined with Building Information Modelling (BIM). Game-engine technology is used due to its intuitive controls, immersive 3D technology and network capabilities that allow for multiple simultaneous users. BIM has been specified due to the growing trend in industry for the adoption of the design method and the 3D nature of the models, which suit a game engine's capabilities.

BackgroundSerine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfamily, and whether there are other novel types of protease inhibitors in animal venom remains unclear.Principal FindingsHere, by screening scorpion venom gland cDNA libraries, we identified the first Ascaris-type animal toxin family, which contains four members: Scorpiops jendeki Ascaris-type protease inhibitor (SjAPI), Scorpiops jendeki Ascaris-type protease inhibitor 2 (SjAPI-2), Chaerilus tricostatus Ascaris-type protease inhibitor (CtAPI), and Buthus martensii Ascaris-type protease inhibitor (BmAPI). The detailed characterization of Ascaris-type peptide SjAPI from the venom gland of scorpion Scorpiops jendeki was carried out. The mature peptide of SjAPI contains 64 residues and possesses a classical Ascaris-type cysteine framework reticulated by five disulfide bridges, different from all known protease inhibitors from venomous animals. Enzyme and inhibitor reaction kinetics experiments showed that recombinant SjAPI was a dual function peptide with α-chymotrypsin- and elastase-inhibiting properties. Recombinant SjAPI inhibited α-chymotrypsin with a Ki of 97.1 nM and elastase with a Ki of 3.7 μM, respectively. Bioinformatics analyses and chimera experiments indicated that SjAPI contained the unique short side chain functional residues “AAV” and might be a useful template to produce new serine protease inhibitors.Conclusions/SignificanceTo our knowledge, SjAPI is the first functionally characterized animal toxin peptide with an Ascaris-type fold. The structural and functional diversity of animal toxins with protease-inhibiting properties suggested that bioactive peptides from animal venom glands might be a new source of protease inhibitors, which will accelerate the development of diagnostic and therapeutic agents for human diseases that target diverse proteases.

van der Waals heterojunctions formed by stacking various two-dimensional (2D) materials have a series of attractive physical properties, thus offering an ideal platform for versatile electronic and optoelectronic applications. Here, we report few-layer SnSe/MoS van der Waals heterojunctions and study their electrical and optoelectronic characteristics. The new heterojunctions present excellent electrical transport characteristics with a distinct rectification effect and a high current on/off ratio (∼1 × 10). Such type-II heterostructures also generate a self-powered photocurrent with a fast response time (<10 ms) and exhibit high photoresponsivity of 100 A W, together with high external quantum efficiency of 23.3 × 10% under illumination by 532 nm light. Photoswitching characteristics of the heterojunctions can be modulated by bias voltage, light wavelength, and power density. The designed novel type-II van der Waals heterojunctions are formed from a combination of a transition-metal dichalcogenide and a group IV-VI layered 2D material, thereby expanding the library of ultrathin flexible 2D semiconducting devices.

The products of Wuhan University with 5-min sampling are used to analyze the characteristics of BeiDou satellite clocks. Two nanoseconds root-mean-square (RMS) variations are obtained for 1-day quadratic fits in the sub-daily region. The relativistic effects of BDS clocks are also studied. General relativity predicts that linear variation of the semimajor axes of geostationary and inclined geosynchronous satellites causes a quadratic clock drift with a magnitude at the 10 -16 /day level. The observed drift is higher than what general relativity theory would produce. Several periodic terms are found in the satellite clock variations through spectrum analysis. In order to identify the origin of the BDS clock harmonics, a correlation analysis between the period or amplitude of the harmonics and properties of the satellite orbits is performed. It is found that the period of the harmonics is not exactly equal to the orbit period, but rather the ratio of the orbit period to clock period is almost the same as that of a sidereal day to solar day. The BDS clocks obey white frequency noise statistics for intervals from 300 s to several thousands seconds. For intervals greater than 10,000 s, all the BDS satellites display more complex, non-powerlaw behavior due to the effects of periodic clock variations.