Of the total 125 subjects enrolled in our present study, 25 cases were of PCa and 100 were healthy controls. The mean value of fasting plasma glucose was 95.5 mg/dl in cases of prostatic carcinoma and the mean value of fasting plasma insulin was 5.78 µU/ml (p value: 0.0001*). The fasting insulin levels µU/ml were categorized into the different ranges starting from ≤2.75, >2.75 to ≤4.10, >4.10 to ≤6.10, >6.10µU/ml. The maximum number of cases of prostatic carcinoma of fasting insulin levels falls in range of >6.10µU/ml. The highest insulin levels (>6.10µU/ml) were seen to be associated with an 2.55 fold risk of prostatic carcinoma when compared with fasting insulin levels of (<2.75 µU/ml). Conclusions: Elevated fasting levels of serum insulin appear to be associated with a higher risk of prostate cancer.
Background: Breast cancer is the second most common malignancy among Nepalese women, accounting for 60% of the total cancer cases in females. Women diagnosed with germline mutations in BRCA1 like 185delAG, 1294del40 develop breast and/or ovarian cancer with a lifelong likelihood of up to 85% whereas presence of a mutation increases the risk for mutations to occur in other genes. The major objective of this study was to find the prevalence of these mutations in Nepalese cancer patients. Materials and Methods: This prospective study was carried out at two cancer hospitals in the Kathmandu valley over a period of 11 months. Irrespective of age group and stage of canceran appropriate amount of blood was withdrawn from 50 breast cancer patients and 20 controls. DNA was extracted manually and subjected to PCR using primers for 185delAG and 1294del40 mutations. PCR products were then digested with restriction enzyme (DdeII) followed by electrophoresis. Results: Prevalence of 185delAG in reference breast cancer patients was found to be 4/50 (8%) but no 1294del40 was apparent. Conclusions: Several mutations occurring in different exons of BRCA1 as well as mutations in other genes like BRCA2, for example, should also be taken in account.
BackgroundHepatitis B is a major public health issue in Nepal. Acute as well chronic Hepatitis B infection can lead to different hepatic manifestation ranging from acute liver failure, aplastic anemia and liver cirrhosis to liver cancer. Although, there is a presence of high burden of viral hepatitis in Nepal but little have been studied about it. So this study was aimed to obtain the seroprevalence of Hepatitis B among all the patients: outpatient as well as patient in different wards visiting a tertiary care hospital.
MethodsThis was a retro prospective study conducted at a tertiary care hospital in which the data was obtained from the university register. The data documents the seroprevalence of Hepatitis B. In this study we have assessed total of 240 samples all of which were processed at Microbiology and Pathology laboratory using commercially available kits. Data were cleaned manually and analyzed using SPSS vs. 20.
ResultsOut of 240 samples assed, 158 were males and 82 females and we found a total viral hepatic burden of 4.19% (10 samples).The mean age group of our study was 47 years (9 years to 85 years). Out of HBsAg screened positive population, HBV was seen mostly in males (90%) whereas lesser in female (10%).
ConclusionsViral hepatitis usually does not follow any seasonal pattern so emphasis must be given to pre-exposure and post-exposure prophylaxis so that we can prevent people from casualties caused via viral hepatitis.
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