Role of Hyperinsulinemia in Increased Risk of Prostate Cancer: A Case Control Study from Kathmandu Valley

Abstract

Of the total 125 subjects enrolled in our present study, 25 cases were of PCa and 100 were healthy controls. The mean value of fasting plasma glucose was 95.5 mg/dl in cases of prostatic carcinoma and the mean value of fasting plasma insulin was 5.78 µU/ml (p value: 0.0001*). The fasting insulin levels µU/ml were categorized into the different ranges starting from ≤2.75, >2.75 to ≤4.10, >4.10 to ≤6.10, >6.10µU/ml. The maximum number of cases of prostatic carcinoma of fasting insulin levels falls in range of >6.10µU/ml. The highest insulin levels (>6.10µU/ml) were seen to be associated with an 2.55 fold risk of prostatic carcinoma when compared with fasting insulin levels of (<2.75 µU/ml). Conclusions: Elevated fasting levels of serum insulin appear to be associated with a higher risk of prostate cancer.

Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies

“…The alteration in fatty acids is related to changes in lipid β-oxidation necessary to provide energy for abnormal cell proliferation (Table 2) [69], [68], [70], [71], [72], [73], [74], [75]. Alterations in energetic metabolism are also common [68], [76] (Table 2), and increased levels of glucose in serum samples at the time of PCa diagnosis were associated with an increased risk of recurrences after therapy with radical prostatectomy or radiation therapy [77].…”

Glucose impairments and insulin resistance in prostate cancer: the role of obesity, nutrition and exercise

“…Several metabolic disorders including obesity and hyperinsulinemia are associated with prostate cancer risk. Lifestyle factors such as excess energy intake and physical inactivity , generally associated with prostate cancer, contribute to a deleterious metabolic profile resulting in insulin resistance, visceral adiposity, pro‐inflammation and hormonal changes .…”

“…Hyperinsulinemia is associated with many cancers, including prostate cancer . In non‐malignant populations, insulin resistance results in decreased insulin sensitivity in peripheral tissue, resulting in hyperinsulinemia to maintain normal glycaemia .…”

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

“…A deeper research into the factors that differ significantly across these continents may answer the questions regarding its incidence and causative factors. The foremost risk factors that may underlie these regional/ethnic differences could be endocrine variations, genetic polymorphisms (ZeiglerJohnson et al, 2002) altered hormonal status (Garfinkel, 1986), socioeconomic status (Nomura and Kolonel, 1991) and obesity and diet (Stephen and Brady, 2005;Girling et al, 2007) Diet, disturbed glucose metabolism, and metabolic syndrome are extremely interesting factors for in depth exploration in relation to the risk of prostate cancer (Long et al, 2012;McGrowder et al, 2012;Tewari et al, 2012;Ozbek et al, 2014, Pandeya et al 2014 In an earlier study, we presented that body mass index and waist to hip ratio were significantly higher in prostate cancer in 1 , Singh Rajender 2 *…”