Glucose impairments and insulin resistance in prostate cancer: the role of obesity, nutrition and exercise

Sebastiano, Katie M. Di; Pinthus, Jehonathan H.; Duivenvoorden, Wilhelmina; Mourtzakis, Marina

doi:10.1111/obr.12674

Cited by 47 publications

(37 citation statements)

References 104 publications

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“…The prevalence of prostate cancer in men might be higher in Western countries due to being a comorbidity to obesity-related diseases like insulin resistance and constant inflammation [ 27 , 28 , 29 , 30 ]. Inflammatory signals in the prostate will enhance proliferation of otherwise normal epithelial cells [ 31 ], which could be a starting point for cancer development.…”

Section: Introductionmentioning

confidence: 99%

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Staal

Beyaert

2018

Cells

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Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and benign. Due to its high prevalence, it is, however, still the second most common cause of death by cancer in men in the West. The higher prevalence of prostate cancer in the West might be due to elevated inflammation from metabolic syndrome or associated comorbidities. NF-κB activation and many other signals associated with inflammation are known to contribute to prostate cancer malignancy. Inflammatory signals have also been associated with the development of castration resistance and resistance against other androgen depletion strategies, which is a major therapeutic challenge. Here, we review the role of inflammation and its link with androgen signaling in prostate cancer. We further describe the role of NF-κB in prostate cancer cell survival and proliferation, major NF-κB signaling pathways in prostate cancer, and the crosstalk between NF-κB and androgen receptor signaling. Several NF-κB-induced risk factors in prostate cancer and their potential for therapeutic targeting in the clinic are described. A better understanding of the inflammatory mechanisms that control the development of prostate cancer and resistance to androgen-deprivation therapy will eventually lead to novel treatment options for patients.

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Section: Introductionmentioning

confidence: 99%

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Staal

Beyaert

2018

Cells

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“…These real-time PCR data indicate that, for investigating HIF1A pathways in vitro , PC3 cells could serve as an appropriate model ( Table 4 ). Patients with Type 2 diabetes develop more aggressive PCa [ 33 , 34 ] and show increased risk of PCa mortality [ 35 ]; therefore, altered glucose metabolism and the upregulation of glucose transporters could be involved in the progression of PCa in patients with diabetes [ 7 , 24 ]. HPEC cells had high GLUT1 expression levels, whereas CWR-R1ca cells showed the highest expression for GLUT12 transcripts, indicating that these cell lines could be used to analyze the involvement of glucose metabolism in cancer progression.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, paracrine factors secreted by PCa cells were shown to stimulate osteoblasts, which led to excess bone formation [ 6 ]. Metabolic alterations, including obesity, metabolic syndrome, insulin resistance, and diabetes, are known to exacerbate PCa [ 7 , 8 ]. These conditions mediate the aggressivity of PCa via endocrine signaling [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Hormone-Dependent Pathways in Six Human Prostate-Cancer Cell Lines: A Gene-Expression Study

Frankó

Berti

Guirguis

et al. 2020

Genes

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Prostate cancer (PCa), the most incident cancer in men, is tightly regulated by endocrine signals. A number of different PCa cell lines are commonly used for in vitro experiments, but these are of diverse origin, and have very different cell-proliferation rates and hormone-response capacities. By analyzing the gene-expression pattern of main hormone pathways, we systematically compared six PCa cell lines and parental primary cells. We compared these cell lines (i) with each other and (ii) with PCa tissue samples from 11 patients. We found major differences in the gene-expression levels of androgen, insulin, estrogen, and oxysterol signaling between PCa tissue and cell lines, and between different cell lines. Our systematic characterization gives researchers a solid basis to choose the appropriate PCa cell model for the hormone pathway of interest.

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“…The relationship between sun exposure and obesity has not been explored in cancer patients. Individuals with breast or prostate cancer are at increased risk of developing obesity, compared to the general population . This may be caused by the modes of action of some cancer treatments, such as chemotherapy, surgery and radiotherapy for breast cancer and hormonal treatments in both breast and prostate cancer .…”

Section: Introductionmentioning

confidence: 99%

Significant Associations Between Sun Exposure and Adiposity Were Not Observed in Breast and Prostate Cancer Patients in a Cross‐sectional Analysis

Zhang

Black

Cooper

et al. 2019

Photochem & Photobiology

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Obesity is a significant health problem worldwide. Exposure to low‐dose ultraviolet radiation (like that in sunlight) suppresses the development of obesity in mice; however, the nature of the associations between sun exposure and adiposity is not well understood in humans. The present study characterized cross‐sectional relationships between sun exposure and adiposity in a convenience cohort of breast (n = 269; mean age = 58 years) and prostate (n = 78; mean age = 69 years) cancer patients. Participants were enrolled in a 3‐month exercise program in Perth, Australia. Self‐reported questionnaires measured time spent outdoors (previous week, winter and summer), sex, age, treatment received and physical activity levels. Adiposity measures included body mass index, waist‐hip ratio and body fat percentage (measured via DXA). In unadjusted models, greater time spent outdoors across all times was significantly associated with lower waist‐hip ratio, while greater time spent outdoors in the last winter was associated with lower body fat percentage, but not when stratified by sex. There were no statistically significant associations between time spent outdoors and adiposity after adjusting for sex, age, treatments received and physical activity. Longitudinal studies in larger populations may elucidate significant associations not found in our study due to the cross‐sectional design and power limitations.

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Glucose impairments and insulin resistance in prostate cancer: the role of obesity, nutrition and exercise

Cited by 47 publications

References 104 publications

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Characterization of Hormone-Dependent Pathways in Six Human Prostate-Cancer Cell Lines: A Gene-Expression Study

Significant Associations Between Sun Exposure and Adiposity Were Not Observed in Breast and Prostate Cancer Patients in a Cross‐sectional Analysis

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