Glycated Hemoglobin (Hba1c) Is a Predictor of Dyslipidemia in Type 2 Diabetes Nepalese Patients.

Maharjan, Pooja; Pandeya, DipendraRaj; Joshi, Govardhan; Hona, Sakrita; Bhatta, Bibek; Hamza, AlneilM.; AlDahr., MohammedH.Saiem

doi:10.21474/ijar01/3121

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Alam et al [1] also reported significant correlations between all components of the lipid profile and glycosylated hemoglobin. Maharjan et al [13], Cohen et al [18] and Arab et al [19] reported significant correlations between glycosylated hemoglobin and TG, TC, LDL and FBS and non-significant correlation with HDL. Babikr et al [2] also reported correlations of HbA1c with LDL.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Khan [12] showed a direct correlation between HbA1c and LDL and TC in diabetics in Saudi Arabia. Maharjan et al [13] showed that HbA1c was a predictor of dyslipidemia among type 2 diabetics. The predictive value of HbA1c varies among races and ethnicities because the rate of glycation and/or RBC life span differs among racial and ethnic groups [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Correlations between Glycosylated Hemoglobin and Lipid Profiles in Newly-Diagnosed Type II Diabetics

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Gb²

2019

J Diabetes Metab

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Introduction: Type II diabetes is a chronic disease which results from aspects such as complex inheritance interaction, obesity, and sedentary lifestyle. In India, diabetes is turning into an epidemic as currently, more than 62 million individuals suffer from the disease. To our knowledge, very few studies have evaluated the correlation between lipid profiles and glycated hemoglobin (HbA1c) in newly diagnosed type II diabetes patients with hypertension. The early detection of lipid abnormalities in these patients will help prevent the cardiovascular outcomes. Objectives: To identify patterns of dyslipidemia among newly diagnosed type II diabetes mellitus (DM) patients with and without hypertension in Bengaluru (urban and rural) in Karnataka (South India); and to identify correlations between HbA1c levels and lipid profiles. Methods: This was a cross sectional study involving 194 individuals in Bengaluru, India from the period of April to December 2017. Demographics, lifestyle habits and clinical features were analyzed for the presence of any interrelationship with the occurrence of diabetic dyslipidemia. One-way analysis of variance (ANOVA), followed by Tukey's post hoc tests, Chi square and correlation studies were used to establish a significant level of association between the study parameters. Results: Among non-diabetics, prediabetics, diabetics and diabetics with hypertension, there were significant differences in lipid profiles, as well as levels total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein (LDL), very low-density lipoprotein, ratios of cholesterol to HDL and ratios of LDL to HDL. Positive correlations were observed between HbA1c and fasting blood sugar (FBS), and random blood sugar (RBS) in non-diabetics; whereas, in prediabetics, the RBS highly correlated with HbA1c and negatively correlated with HDL. In diabetics, both fasting and random blood sugar highly correlated with HbA1c, however, no significant correlation was observed between HbA1c and any of the tested lipid profiles in non-diabetics and diabetics. A strong correlation between HbA1c and lipid profiles was established. Conclusion: An overweight diabetic man with poor glycaemic control, over the age of 46 years, having a desk job or working as a driver or businessman, with abdominal obesity, leading a sedentary lifestyle and having habits such as alcohol drinking and smoking is at high risk for developing hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlations between Glycosylated Hemoglobin and Lipid Profiles in Newly-Diagnosed Type II Diabetics

Sn¹,

Gb²

2019

J Diabetes Metab

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“…Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and / or insulin action. 1 Diabetes mellitus (DM) is one of the common noncommunicable diseases and it is one of the most challenging health problems in the 21 st century. 2 There are two general types of diabetes mellitus, one is type 1 or insulin dependent DM (IDDM) and other is type 2 or non-insulin dependent DM.…”

Section: Introductionmentioning

confidence: 99%

Serum Triglycerides and Total Cholesterol levels and its Relation with type 2 148 Diabetes mellitus

et al. 2020

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Diabetes mellitus is one of the most widespread endocrine disorder in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and end stage renal diseases. A relation between hyperlipidemia and diabetes mellitus has been identified. The study was carried out to observe the serum triglycerides and total cholesterol levels its relation with type 2 diabetes mellitus in adult female subjects. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of sixty female subjects were selected with age ranging from30 to50 years. Among them 30 female subjects with diabetes were included from out-patient department of Endocrinology, Dhaka Medical College Hospital, Dhaka as study group(B) and 30 apparently healthy female were taken as control group(A) for comparison. Estimation of fasting serum triglycerides (TG) and total cholesterol (TC) levels were done by enzymatic method in the Department of Physiology, Dhaka Medical College Dhaka in both groups. Fasting serum insulin level was measured by ELISA method in the Department of Laboratory of National Institute of ENT, Dhaka and fasting blood glucose was estimated by glucose oxidase method in Department of Dhaka Medical College in both groups. Data were analyzed by Unpaired Student’s- test and Pearson’s correlation co-efficient (r) test as applicable. The value of fasting serum TG and TC level were significantly higher in study subjects than those of control. In study subjects fasting serum TG and fasting serum TC levels showed positive correlation with fasting blood glucose and serum insulin level. Conclusion: Present study revealed that fasting serum triglyceride (TG) and fasting serum cholesterol (TC) levels have positive relationship with fasting serum insulin and fasting blood glucose levels. J Dhaka Medical College, Vol. 27, No.2, October, 2018, Page 148-154

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“…China [16]. Not only these study reports differed from each other, but also the fact that no studies have been conducted so far in South India to find the existence and pattern of dyslipidemia among prediabetic individuals so that early detection and timely action will reduce the economic burden on the country due to the prevention of progression of prediabetes into Type 2 Diabetes Mellitus [17,18]. It is a well-known fact that the HbA1c level as a predicting factor differs among races and ethnicity as the rate of glycation and RBC life span differs among racial and ethnic groups [19,20].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Hba1c, decreased HDL and Abdominal Obesity in Prediabetics of Karnataka State, South India

Gb²

2020

Diab Res Open Access

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This study aims to explore the possibility of the existence of dyslipidemia among prediabetics in India and to find the correlation if any, present between their glycated hemoglobin (HbA1c) levels and their lipid profile, and to identify the risk factor(s) if any, for the onset of diabetes. A cross-sectional study involving 212 individuals in Bangalore of Karnataka State, India from the period of August 2017 to February 2019 was considered for the study. Within the lipid profile, High-Density Lipoprotein (HDL) and the ratio of cholesterol to HDL displayed statistically significant differences between the means of the population of healthy nondiabetics and prediabetics. In prediabetics, HbA1c was negatively correlated with HDL. so, testing of HDL and cholesterol to HDL ratio at regular intervals for prediabetics should be made mandatory, as they fall in the risk category for developing type 2 Diabetes and this regular screening of HDL and Cholesterol to HDL ratio will prevent prediabetics from progressing into type2 diabetes later on. Regarding demographic factors, abdominal obesity was found to be statistically significantly associated with prediabetes. Hence prediabetics should follow a regular exercise regime to prevent themselves from progressing into diabetes in their later years.

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Glycated Hemoglobin (Hba1c) Is a Predictor of Dyslipidemia in Type 2 Diabetes Nepalese Patients.

Cited by 8 publications

References 10 publications

Correlations between Glycosylated Hemoglobin and Lipid Profiles in Newly-Diagnosed Type II Diabetics

Correlations between Glycosylated Hemoglobin and Lipid Profiles in Newly-Diagnosed Type II Diabetics

Serum Triglycerides and Total Cholesterol levels and its Relation with type 2 148 Diabetes mellitus

Correlation between Hba1c, decreased HDL and Abdominal Obesity in Prediabetics of Karnataka State, South India

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