Novel Y-shaped acceptor-pi-donor-pi-acceptor-type compounds, synthesized from 4,4'-hexyliminobisbenzaldehyde as electron donors and different active methylene compounds as electron acceptors, were produced by conventional Knoevenagel condensation alone, with a deep eutectic solvent, or with a lipase biocatalyst to compare the yield and recyclability among the three methods. Yield, reaction time, reaction temperature, and recyclability were compared among the three methods. The photophysical properties and thermal stability of the products were also investigated.
A series of novel dihydropyrimidin-2(1H)-ones derivatives was synthesized by using Rhizopus Oryzae lipase biocatalyst in deep eutectic solvent. The reaction is characterized by high efficiency and selectivity, short reaction time, mild and environmentally friendly reaction conditions. The yields were found to be significantly higher and reuse of both the lipase and deep eutectic solvent was possible up to four consecutive cycles. The products are found to exhibit appreciable in vitro antibacterial activity against Echerichia coli, Pseudomonas neumoniae and in vitro antifungal activity against Aspergillus niger and Candida albicans.
MIC, minimal inhibitory concentration values; bacterial strain, E. coli and S. aureus; fungal strain, C. albicans and A. niger; solvent used, DMSO; standard: bacterial strain, streptomycin 125 mg/mL; fungal strains, fluconazole 125 mg/mL.
1352V. S. Padalkar, B. N.
A series of 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole derivatives have been synthesized from intermediate 1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol. This intermediate was obtained by coupling 3-(1,3-benzoxazol-2-yl)naphthalen-2-ol with 4-sulphobenzenediazonium chloride followed by reduction with sodium dithionate in water at pH 8-9. 3-(1,3-benzoxazol-2-yl)naphthalen-2-ol was synthesized from 3-hydroxynaphthalene-2-carboxylic acid and 2-amino phenol in the presence of PCl 3 in chlorobenzene at 130-135 • C. All these compounds were characterized by FT-IR, 1 H NMR, mass spectral and elemental analysis. The synthesized compounds are fluorescent which absorbs in the range of 296 to 332 nm while emits in the ranges of 368 to 404 nm with excellent quantum yield. All compounds were evaluated for in vitro antibacterial activities against Escherichia coli and Staphylococcus aureus strains and in vitro antifungal activity against Candida albicans and Aspergillus niger strains by using serial dilution method.
Properties. -The title compounds such as (III), (V), and (VII) are obtained by Knoevenagel condensation under classical, conventional condition, in the presence of a lipase biocatalyst or with a deep eutectic solvent (DES). Best results with respect to product yields and mildness are achieved using lipase and DES. Compounds (III), (V), and (VII) show appreciable in vitro antibacterial activity against E. coli, P. neumoniae, and Micrococcus, and in vitro antifungal activity against A. niger and C. albicans. -(BORSE, B. N.; SHUKLA*, S. R.; SONAWANE, Y. A.; SHANKERLING, G. S.; Synth. Commun. 43 (2013) 6, 865-876, http://dx.
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