Synthesis of Some Novel Pyrimidinedione and Pyrimidinetrione Derivatives by a Greener Method: Study of Their Antimicrobial Activity and Photophysical Properties

Borse, Bhushan Nanasaheb; Shukla, S. R.; Sonawane, Yogesh A.; Shankerling, Ganpati Subray

doi:10.1080/00397911.2011.611324

Cited by 18 publications

(11 citation statements)

References 16 publications

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“…For instance, ChCl‐U was used as catalyst/solvent for mono N ‐alkylation of aromatic amines, with recycling achieved by simple biphasic extraction with ethyl acetate. The development of condensation reactions in DESs has been particularly interesting, as exemplified by the use of ChCl‐U for the synthesis of pyrimidinedione and pyrimidinetrione by condensation of different aldehydes with barbituric acids . The DES mixture utilized could be reused up to three times, with further recycling resulting in considerably reduced yields.…”

Section: Roles Of Dess In Chemical Processesmentioning

confidence: 99%

“…The development of condensation reactions in DESs has been particularly interesting, as exemplified by the use of ChCl-U for the synthesis of pyrimidinedione and pyrimidinetrione by condensation of different aldehydes with barbituric acids. 80 The DES mixture utilized could be reused up to three times, with further recycling resulting in considerably reduced yields. More recently, NADESs based on D-glucose/racemic malic acid have been used as media for an enantioselective L-proline-catalyzed intermolecular aldol reaction between ketones and aldehydes.…”

Section: Media For Reactionsmentioning

confidence: 99%

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Deep eutectic solvents: designer fluids for chemical processes

Wazeer

Hayyan

Hadj-Kali

2017

J of Chemical Tech & Biotech

110

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The increasing demand for multi‐task green solvents has spurred the development of next‐generation liquid media such as deep eutectic solvents (DESs), which have recently attracted increased attention. DESs are mixtures of salts and complexing agents, having freezing points lower than those of starting individual components. Similarly to ionic liquids, DESs exhibit distinctive properties such as chemical and thermal stability, biodegradability, non‐flammability, and cost effectiveness. These features account for their wide range of applications, e.g. as extractants, reactants, catalysts, reaction media, additives, and lubricants. This review summarizes the recent research efforts directed at exploring the potential applications of DESs in various chemical processes. With the rapid publication of reports on this new generation of solvents, other roles also are expected to be seen sooner or later. © 2017 Society of Chemical Industry

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Section: Roles Of Dess In Chemical Processesmentioning

confidence: 99%

Section: Media For Reactionsmentioning

confidence: 99%

Deep eutectic solvents: designer fluids for chemical processes

Wazeer

Hayyan

Hadj-Kali

2017

J of Chemical Tech & Biotech

110

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“…The DES media was reused up to three times, after which the yield decreased considerably. [100] In the second one, despite of being a simple Knoevenagel condensation between active methylene compounds and aromatic aldehydes, the use of DES mixture in catalytic amounts has proved very effective, the medium being recycled up to five times without any apparent loss in the yield [equation (b) in Scheme 28]. [101,102] Scheme 28.…”

Section: Condensation Reactionsmentioning

confidence: 99%

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

et al. 2016

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This microreview summarizes the use of deep eutectic solvents (DES) and related melts in Organic Synthesis. This type of solvents combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high availability, low inflammability, high recyclability, low volatility and low price, avoiding many disadvantages of these neoteric media. The fact that many of the components of the mixture come directly from Nature assures their biodegradability and renewability. The classification and distribution of the reactions in different sections along this microreview, as well as the emphasis paid to their scope, easily allows a general reader to understand the actual state of art, and the great opportunities opened, not only for academic proposes but also for industry.

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“…A screening of different lipases has shown that the best activity (assessed by soybean oil methanolysis) was, once again, obtained with the immobilized lipase B from Candida antarctica (iCALB). They also confirmed the remarkable stability of iCALB in a DES based on cholinium acetate and glycerol (ChOAc:Gly), with a residual activity maintained at 92% and 50% after 48 h and 168 h. Finally, Borse et al were able to accomplish with success a multi-component synthesis of a series of novel pyrimidinedione-and pyrimidinetrionesbased compounds using the Rhizopus Oryzae lipase, with reaction yields between 73% and 95% in only 6 h (Borse et al, 2013). Also, the influence of the DES has proven to be beneficial and critical to the reaction since lower yields were obtained using other reaction media such as water, methanol, dioxane or DMF.…”

Section: Lipase-catalyzed Lipophilisation In Desmentioning

confidence: 57%

Are emerging deep eutectic solvents (DES) relevant for lipase-catalyzed lipophilizations?

Durand

Lecomte

Villeneuve

2015

OCL

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-With the recent interest on green chemistry, the scientists have focused on developing new and more efficient solvents to carry out enzymatic-catalyzed reactions with emphasis on reduced costs, risks and toxicity while improving biodegradability. Among the new available solvents, the multimolecular-based liquids (such as ionic liquids and eutectic solvents) have been the subject of most recent studies. Currently, and mainly due to its environmental and economic features, DES are arousing much interest and curiosity. Regarding the biotransformations with lipases, the so-called "lipophilization" reactions are of major interest. However, they are complex to implement mainly because it is difficult to find a suitable reaction medium. Thus, this review aimed at providing a presentation of these multimolecularbased solvents with general overview of the recent studies dealing with lipase-catalyzed reactions in DES. In addition, emphasis was placed on their strengths and weaknesses, especially with the perspective to be use as efficient and green medium to implement complex and valuable biotransformation such as lipase-catalyzed lipophilizations.Keywords: Low transition temperature mixtures / deep eutectic solvents / Lipase / Lipophilization Résumé -Solvants de type eutectiques profonds : milieux réactionnels adaptés aux réactions de lipophilisation biocatalysées par les lipases ? Depuis le début des années 1990 et l'émergence de la « chimie verte », il est indispensable de concevoir des nouveaux procédés, en particulier enzymatiques, qui mettent l'accent sur la réduction des coûts, des risques et de la toxicité tout en améliorant la biodégradabilité. Les nouveaux solvants de type « liquides multimoléculaires » (tels que les liquides ioniques et les solvants eutectiques) ont fait l'objet de la plupart des études récentes. Actuellement, et principalement en raison de ses atouts environnementaux et économiques, les solvants eutectiques suscitent beaucoup plus d'intérêt et de curiosité. Concernant les biotransformations lipasiques, les réactions dites « de lipophilisation » présentent de nombreux avantages. Cependant, ces réactions sont complexes à mettre en oeuvre, principalement parce qu'il est difficile de trouver un milieu réactionnel adapté. Ainsi, cette revue a pour objectif de fournir une présentation de ces milieux réactionnels avec un aperçu des travaux récents portant sur les réactions lipasiques dans des solvants eutectiques. En outre, l'accent a été mis sur leurs forces et leurs faiblesses, avec la perspective d'être utilisés comme milieu réactionnel « vert » pour mettre en oeuvre des biotransformations complexes telles que les réactions de lipophilisation biocatalysées par les lipases. Mots clés :Mélanges à faible transition de température / solvants eutectiques profonds / lipase / lipophilisation

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Synthesis of Some Novel Pyrimidinedione and Pyrimidinetrione Derivatives by a Greener Method: Study of Their Antimicrobial Activity and Photophysical Properties

Cited by 18 publications

References 16 publications

Deep eutectic solvents: designer fluids for chemical processes

Deep eutectic solvents: designer fluids for chemical processes

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

Are emerging deep eutectic solvents (DES) relevant for lipase-catalyzed lipophilizations?

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