Introduction: Prevalence of mental illnesses among adolescents was found 7.3% (N=1191) by NMHS survey 2015-16 whereas the national crime record bureau in 2014 stated 1.8% of students committed suicide due to failure in their exams. The root cause, that is academic stress is often ignored which occurred due to various stressors like physical, mental, family, school, relationship, and social factors of which School factor (56.7%) and academic tests (45.6%) hold maximum association. Proper management can be provided with Ayurveda by Prakriti wise (exploring one physical, physiological and psychological factors) analysis of stress and their coping up strength and effect, when assisted with oral intakes of Ayurveda drugs like Brahmi and Haritaki along with Sattvavajaya Chikitsa having Achar Rasayana, Surya Namaskar, Dharna, and Dhyana practices. Aim and Objectives: The aim is to evaluate the comparative efficacy of Brahmi extract with Sattvavajaya Chikitsa over the effect of Haritaki extract with Sattvavajaya Chikitsa in the management of Academic Stress among adolescent students of different Prakriti. Material and Methods: A double-blind reference standard controlled stratified randomized superiority clinical trial is planned. The sample size of 198 participants with 13% dropout consideration will be enrolled after analysis of their Prakriti and stress level between 5-25 according to the SAAS scale. Total 6 subgroups (3 each for trial drug group and 3 for standard control) will have Vata, Pitta, and Kapha Doshic (V, P & K) dominant Prakriti participants of 10 to 17years of age. Total 33 participants in each subgroup will have the interventions for 90 days. Observation and Results: Participants will be assessed for changes in salivary cortisol, level of academic stress, IQ, and memory before and after the trial. The standard descriptive and inferential statistical measures will be used to assess the effect of interventions. Conclusion: Prakriti analysis will help stressed adolescents to know their strengths and interventions provided will be expected to help a stressed one to minimize stress level and also assist in developing their stress-coping mechanism.

No abstract

No abstract

COVID- 19 has created a lot of hazardous health issues worldwide. Research fraternity around the world is trying to find out vaccine or medicines against the virus. In this pandemic situation, there is a need for remedies to boost the immunity to fight against the virus. Ayurveda treatises have described several herbal drugs which are used as home remedies and are said to be effective against all microorganisms and effective in boosting immunity. Home remedies can be played a vital role as immunomodulant. Hence in this paper, an attempt is made to review such home remedies and identify its efficacy on various conditions. The relevant references were searched on the internet to find out the scientific data available on home remedies. Fumigation, Rasayan drugs, a decoction of herbal medicines found more useful. Tinospra cordifolia, Glycyrrhiza glabra, Ocimum sanctum, Withania somnifera, Curcuma longa are most decorated single herbal drugs used as home remedies for boosting the immunity. Considering the global disease burden caused by COVID-19, there is an urgent need to explore and widened the use of home remedies to fight against COVID-19 menace effectively.

Aim: The main aim of the present study is in vitro assessment of the diffusion ability and degradation of calcium hydroxide from pastes prepared by using different vehicles to determine the influence of a vehicle on pH of calcium hydroxide [Ca(OH) 2 ] pastes. Materials and methods: A total of 44 single-rooted premolar teeth were used in this study. The tooth crowns were removed and the root canals were prepared. Depending on the vehicle to be used for preparing calcium hydroxide pastes, four groups were made: group I: Ca(OH) 2 saline paste (control group), group II: Ca(OH) 2 neem , group III: Ca(OH) 2 aloe vera , group IV: Ca(OH) 2 turmeric paste. After biomechanical preparation, calcium hydroxide herbal paste dressings were applied and sealed with resin-based cement. The teeth were placed in containers with distilled water, and the pH of the water was measured at regular intervals over 3, 24, and 168 hours. Results: The present study showed all herbal pastes allowed the diffusion of ions, but pastes prepared with aloe vera showed more ion diffusion and a marked increase in pH, depicting better support for calcium hydroxide action. Conclusion: Aloe vera allows better diffusion of calcium hydroxide through dentinal tubules, thus enhancing its action, and advises its use as a vehicle for placing intracanal medicament. Clinical significance: Calcium hydroxide [Ca(OH) 2 ] is the most common and effective intracanal medicament. However, CH is not so effective when used alone. Therefore combinations are required to enhance its clinical properties. To be effective, diffusion of hydroxyl ions are required for which vehicle plays a significant role.

Urinary tract infections (UTI) in all ages are related with high morbidity and long term difficulties. Use of antibiotics is useful in cases of UTI, consequently opposition of pathogenic microorganisms to antibiotics  is of high clinical concern. According to Ayurveda drugs especially important components which have been utilized for the treatment of various diseases. The review paper highlighted different clinical studies and scientific studies which are useful to prove the adequacy of Ayurveda drugs against urinary tract infections. Ayurvedic  drugs were reviewed in the current paper in the awake of evaluating their well being for the clinical condition like UTI. Ayurvedic medications showed good anti bacterial properties against both gram positive and negative microscopic organisms causing UTI. Other aspects are highlighted  likewise mitigating, diuretic, cell reinforcement, nephroprotective and antiurolithiatic properties helpful in the administration of UTI and all medications are protected even in high dosages subsequently can be adequately utilized for UTI conditions. In this paper an attempt is made to highlight the research work of herbal drugs of Ayurveda which would be effective in the treatment of UTI.

Background: 20% to30 % elderly population suffers with Musculoskeletal disorders such as Multiple joint pains, Low back pain, Rheumatoid arthritis, Osteoarthritis. Multiple treatment modalities are in vogue to treat MSDs all over the world but neither provides adequate pain relief nor modifies the disease process. Hence majority of the tribal population prefer traditional healers for treating MSDs as they are safe, effective, inexpensive and easily available. Aim & Objectives: Quantitative analysis of Medicinal plants used by the traditional healers of Karanja block of Wardha district for treating musculoskeletal disorders. Material & Methods: The survey study was carried out through field visits. Questionnaire, personal interviews and discussions with the traditional healers were used for data collection. Specific pharmacological properties of herbal drugs used by the traditional healers to treat MSDs were authenticated by taxonomist and forest range officer and verified through Nighantus and Samhitas. Observations & results: Total 17 traditional healers were interviewed for data collection. Total 23 plant species belonging to 20 families were indentified and documented for the treatment of MSDs.  Tribal utilized 9 varieties of plant parts from 4 types of habitat and treat the patients of MSDs with 5 types of medicinal preparations through external and internal applications.

Background: Shukti (Oyster) is a very commonly occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two forms which are bhasma (calcinated ash) and pishti (powdered form without agni).These forms may have different rate of absorption. This needs to be studied. Aim: To study Pharmaceutico-analytical study of Muktashukti pishti & Muktashukti bhasma and comparative evaluation of their relative oral bioavailability. Materials and methods: The two formulations will be prepared from shukti (oyster). By triturating with Gulabjala Muktashukti pishti will be prepared and by traditional puta method Muktashukti bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, physicochemical parameters and Particle size distribution analysis, SEM-EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), GCMS (Gas Chromatography Mass Spectrometry) will be evaluated. To assess the relative oral bioavailability of Muktashukti pishti & Muktashukti bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement. The study will be conducted in between two test groups and standard group. Observation and results: The analytical parameters will be assessed and compared in Muktashukti bhasma and Muktashukti pishti. For relative oral bioavailability Blood serum calcium will be assessed in all three groups. By applying unpaired “t” Test, One-way ANOVA the statistical significance can be measured. Conclusion: The pharmaceutical & analytical study of Muktashukti pishti and Muktashukti bhasma will provide the standard parameters and clinical comparative evaluation with standard will generate evidence for better bioavailability.