In this study, a new naphthalene-prazosin derivative (compound 5) was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the compound 5 on ischemia/reperfusion injury. Additionally, the mechanism of action involved in the activity exerted by the compound 5 on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; prazosin, metoprolol, indomethacin and nifedipine. The results showed that the compound 5 reduced infarct size compared with the control conditions. Other results showed that the compound 5 significantly increases (p = 0.05) the perfusion pressure and coronary resistance in isolated rat heart. In addition, other data indicate that the compound 5 increases left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05) and this effect was independent of cAMP levels. In conclusion, these data suggest that the naphthalene-prazosin derivative exerts a cardio protective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in a decrease of * Corresponding author. B. Sarabia-Alcocer et al. 1131 myocardial necrosis after ischemia and reperfusion.
There are reports which indicate that some steroid derivatives have activity atcardiovascular level; nevertheless, there is scarce information about the effects exerted by the progesterone derivatives on cardiac injury caused by ischemia/reperfusion. In this study, a new steroid (progesterone derivative) was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of progesterone derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the progesterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; mifepristone, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the progesterone derivative reduces infarct size compared with control. Other results showed that the progesterone derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the progesterone derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that progesterone derivative exert acardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.
Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2. The results showed that the testosterone derivative significantly increases (P = 0.05) the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001–100 nM); however, this phenomenon was significantly inhibited (P = 0.06) by indomethacin and PINANE-TXA2 (P = 0.05) at a dose of 1 nM. In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation.
Objective of this work was to study the blood levels of glucose, cholesterol and triglycerides, and their association with eating habits in inhabitants of the community of Tenabo, Campeche, Mexico. Methodology Anthropometric measurements were made to the inhabitants who ranged in age from 10 to 80 years old. Mean glucose levels were 132.86 mg/dL, cholesterol 139.640 mg/dL, and triglycerides 189.2 mg/dL. According to the applied survey, the diet of this population consists of the consumption of meat from wild animals in the region, as well as foods with a high fat content such as pork, in addition, a low consumption of vegetables and fruits is reported among the inhabitants. Results: In this population, glucose and triglyceride levels are elevated compared to the reference values; however, it is necessary to investigate other biochemical parameters that help the timely diagnosis of this type of disease.
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