Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an Ischemia/Reperfusion Model

Abstract

Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2. The results showed that the testosterone derivative significantly increases (P = 0.05) the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001–100 nM); however, this phenomenon was significantly inhibited (P = 0.06) by indomethacin and PINANE-TXA2 (P = 0.05) at a dose of 1 nM. In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation.

Retracted: Facile synthesis of two oxocan derivatives using some chemical strategies

“…For several years, there has been a great interest in the development of heterocyclic compounds in the chemical and pharmaceutical industry. [ 1–3 ] In this way, several oxacycle derivatives have prepared using different strategies; for example, the synthesis of an oxepan from an epoxide derivative and boron trifluoride etherate. [ 4 ] Besides, a study showed the preparation of some Δ 4 ‐disubstituted oxepen analogs via reaction of γ‐triphenylsilyl bishomoallylic with alcohol derivative in the presence of FeBr 3 .…”