Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.
Supplementary information
The online version of this article (doi:10.1038/nature14594) contains supplementary material, which is available to authorized users.
In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera and the creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).
In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
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This study was funded by European Union's Horizon 2020 research and innovation programme, Directorate-General for International Cooperation and Development of the European Commission, Institut national de la santé et de la recherche médicale (INSERM), German Research Foundation (DFG), and Innovative Medicines Initiative 2 Joint Undertaking.
Members of the family Filoviridae produce variously shaped, often filamentous, enveloped virions containing linear nonsegmented, negative-sense RNA genomes of 15-19 kb. Several filoviruses (e.g., Ebola virus) are pathogenic for humans and are highly virulent. Several filoviruses infect bats (e.g., Marburg virus), whereas the hosts of most other filoviruses are unknown. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on Filoviridae, which is available at www.ictv.global/report/filoviridae.
SARS-CoV-2,
the virus responsible for the current COVID-19 pandemic,
displays a corona-shaped layer of spikes which play a fundamental
role in the infection process. Recent structural data suggest that
the spikes possess orientational freedom and the ribonucleoproteins
segregate into basketlike structures. How these structural features
regulate the dynamic and mechanical behavior of the native virion
are yet unknown. By imaging and mechanically manipulating individual,
native SARS-CoV-2 virions with atomic force microscopy, here, we show
that their surface displays a dynamic brush owing to the flexibility
and rapid motion of the spikes. The virions are highly compliant and
able to recover from drastic mechanical perturbations. Their global
structure is remarkably temperature resistant, but the virion surface
becomes progressively denuded of spikes upon thermal exposure. The
dynamics and the mechanics of SARS-CoV-2 are likely to affect its
stability and interactions.
In October 2018, the order Mononegavirales was amended by the establishment of three new families and three new genera, abolishment of two genera, and creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).
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