This study includes 10 samples isolated from a different source. This research paper was to study the antibacterial activity and antibiofilm activity of an alcoholic extract of Lemon Myrtle (Backhousia citriodora) leaves, against 10 clinical isolates of Pseudomonas aerogenoza. Isolates were diagnosed by the VITEK-2 compact system and (PCR). The capacity of isolates to produce biofilm was tested by using the Microtiter plate technique (96 wells). The results showed that isolates were able to form a biofilm, also the ability of Backhousia citriodora was been effective on bacteria and biofilm formation.
This research aimed to study the antibacterial activity and Antibiotic effect of hot aqueous extract of leaves of Ziziphus spina Christy (Sidr),against clinical isolate of Staphylococcus wernari. four isolates were initially diagnosed as Staphylococci bacteria, then one isolation was chosen depending on its sensitivity and resistance to several different types of antibiotics. The VITEK-2 compact system (ID and AST) and PCR were used to confirm the type of staphylococcal isolates . The results showed that one isolate was due to Staphylococcus wernari. the ability of isolate to form biofilm was tested using the Microtiter plate method (96 wells). The results indicated that the extracted isolate was able to produce a biofilm. Where there was a clear effect of moxifloxacin and penicillin G with (MIC), (Sub-MIC) and (Sub-MIC) in inhibiting the growth of bacteria, A significant (P < 0.001).Synergistic effect between Penicillin G, Moxifloxacin with (MIC), (Sub-MIC) and (Sub-MIC) were tested with hot aqueous extract of Ziziphus spina christi (Sidr) leaves with 50 mg/mL. The results showed a high synergy between two types of antibiotics and plant extracts.
Background: Bacterial biofilms may play a role in pathogenesis which has led to increased focus on identifying diseases that may be associated with biofilms. Chronic biofilm infections are usually chronic in nature, as the bacteria that live in biofilms can be resilient to both the immune system and antibiotics and other treatments. Current knowledge of how biofilms contribute to disease pathogenesis suggests a number of different mechanisms. This extends from biofilms being merely a reservoir of pathogenic bacteria, to playing a more active role, for example, by contributing to inflammation. This knowledge is important for developing effective treatment strategies for such infections.
Background: Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen. The prevalence of H. pylori infections varies worldwide. prevalence among middle-aged adults is over 80 percent in many developing countries, as compared with 20 to 50 percent in industrialized countries. The infection is acquired by oral ingestion of the bacterium and is mainly transmitted within families in early childhood, Humans can also become infected with Helicobacter heilmannii, a spiral bacterium found in dogs, cats, pigs, and nonhuman primates. Conclusion: H. pylori infection stimulates the reaction of autoantibodies with gastric epithelial cells, and this leads to gastritis. These autoantibodies can be directly induced to epithelial cells by activating complement, inducing apoptosis or provoking an antibody-dependent cytotoxic reaction resulting in subsequent tissue destruction.
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