Present data clearly demonstrate for the first time that amateur kickboxing is a novel cause of hypopituitarism and kickboxers are at a risk for hypopituitarism especially isolated GH deficiency. Therefore, participants of the combative sports who were exposed to chronic repetitive head trauma need to be screened.
The aim of this study was to investigate the effects of 12 min run test on oxidative stress, some antioxidant enzyme activities, and muscle and DNA damage. Twenty two healthy and well trained male athletes were recruited to this study. The12 min run test, cooper test, was applied to the participating athletes. The blood samples were taken before, immediately after and 24 h after the run test, and sera and plasma were separated and then stored at -80°C until the analysis. Serum MDA and NO levels as the indicators of oxidative damage; serum SOD and CAT, plasma GPx activities as the indicators of antioxidant defense system; serum 8-OHdG as the indicator of DNA damage, CK and LHD enzyme activities as the indicators of muscle damage, and glucose level were measured. Serum SOD, NO, CAT, and 8-OHdG levels showed no significant changes before, immediately after and 24 h after the run rest. There was a significant decrease in serum MDA level immediately after exercise, which is returned to baseline level after 24 h-rest period (p<0.05). Serum LHD (p<0.001) and CK activities (p<0.05) and glucose level (p<0.001) increased immediately after exercise but these increments returned to pre-exercise level after 24 h-rest period. Acute twelve minute endurance exercise increased CK, LDH and glucose decreased oxidative stress and whereas has no effect on antioxidant capacity and DNA damage in trained young men.
Y üksek irtifa hipoksi ve hipoksik egzersiz oksidatif DNA hasarına neden olabilir. Çalışmamız 1055m ve 2500m'de yapılan egzersizin mikronükleus (MN) sıklığı üzerindeki etkisi araştırıldı. MN frekansı, kromozomal hasarın, genom kararsızlığının bir biyolojik işaretidir. 10 erkek, 10 kadın toplam 20 sağlıklı denek çalışmaya dahil edildi. Her iki yerde 5 gün boyunca günde 3 saat egzersiz yaptılar. Egzersizden önce ve egzersizden hemen sonra 1055 m ve 2500 m yükseklikte periferik kan örnekleri hem birinci hem de beşinci günde kültürlendi. Hastaların mitojenle uyarılmış lenfositlerinden elde edilen çift çekirdekli hücrelerde MN değerlerinin sayısı kaydedildi. 1055m koşullarında yapılan egzersizin MN oluşumunu indüklediğini bulduk (p <0.001); 2500 m'de yapılan egzersiz, insan lenfositlerinde daha fazla MN oluşumuna neden olmuştur (p <0.001). Ayrıca, on gün sonra dağdan 1055 m'ye geri inen deneklerin MN frekansları, beş günün sonunda 2500 m rakımdakinden daha düşüktü (p <0.001). Ayrıca, bu MN frekansı, 1055 m'deki bazal MN frekansına benzerdi (p> 0.05). Sonuçlarımız egzersiz ve rakımın kromozomal DNA hasarına neden olabileceğini ve mutajenik etkilere yakından görülebileceğini göstermiştir.
Various studies have been made about effects of exercise on blood parameters. There are different results which probably depend on the methods and various features of subject used in these studies. The aim of this study was to compare the effects of submaximal exercise on some blood parameters in trained and untrained subjects who have similar special features. This study was performed on 20 healthy male volunteers divided into two groups(trained and untrained). At the first day, aerobic capacity of them were evaluated by Physical Working Capacity (PWC170) test. At the second day, each volunteer exercised on bicycle ergometer about 50 % intensities of aerobic capacity. The alterations of blood paraıneters were determined before, immediately after and 24 hours after the exercise. Ali the changes retumed normally 24 hours after the exercise. There were no difference between trained and untrained group.
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