The Effect of Borax on Hematological Parameters and Immunoglobulin Values in Rats

Keklik, Ertuğrul; Nacak, Muradiye; Bakkaloğlu, Umut; Yürük, Merve; Çoksevim, Bekir

doi:10.7727/wimj.2016.359

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The current findings were somewhat similar to the findings of (38)(39)(40)(41), whereas all previous authors recorded a significant reduction in the hematological parameters in mice, rats, and fish, respectively after boric acid administration. The current results were in contrast with the findings of (42).…”

Section: Discussionsupporting

confidence: 91%

Effect of boron on some organs of pregnant BALB/c mice

Salah¹

2021

IJVS

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Current research had been conducted to assess the impact of boric acid (boron) on the different tissues of the fetal and maternal bodies of pregnant mice Mus musculus and its influence on the maternal plasma biochemistry, hematology, in addition to the fetal and maternal bodies weight, moreover the weight of a certain motherly tissues included liver, kidney, lung, brain and spleen. The pregnant mice were administered orally with boric acid at the concentrations of 50 and 100 mg/kg during pregnancy. The observations at a concentration of 50 mg / kg demonstrated several histopathological patterns in different mothers and fetal body parts. The lesions were increased at the dose of 100 mg / kg. Moreover, boron caused weight decrease in the maternal body weight, fetuses, and liver, but it caused an increase in weight of the kidney at the concentration 100 mg/ kg. The biochemical assessment of the maternal serum showed a high rise in the level of liver enzymes, blood urea, creatinine, total protein, total bilirubin, glucose, cholesterol, triglycerides, HDL, and LDL at the concentration 100mg mg/kg. Furthermore, there was a meaningful change in the blood hematology at the concentration 100mg/kg. In conclusion, the exposure of pregnant mice to high concentrations of boric acid can alter the structure, the function of maternal and embryos organs by inducing oxidative stress, which in turn resulting in the accumulation of toxins in the blood that cause different effects during the exposure period.

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Section: Discussionsupporting

confidence: 91%

Effect of boron on some organs of pregnant BALB/c mice

Salah¹

2021

IJVS

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Free Radical Scavenging Activity of Boron and Vitamin C in Nitrite-Induced Hemoglobin Oxidation Model: In vitro and in vivo Studies

Hama Salh,

Aziz,

Ahmed

et al. 2023

Al-Rafidain J Med Sci

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Objective: To investigate the dose-response relationship of the free radical-scavenging activities of boron and vitamin C in nitrite-induced hemoglobin oxidation in vitro and in vivo. Method: Different concentrations of boron and vitamin C were added to a hemolysate challenged with nitrite to induce methemoglobinemia (MetHb), and the most effective dose of boron and vitamin C was used before and after different intervals of inducing Hb oxidation, and the production of MetHb was monitored using a spectrophotometer. The effective doses of boron and vitamin C, alone and in combination, were administered to rats before challenging them with an oral dose of 100 mg/kg sodium nitrite. Results: In vitro results indicated that different concentrations of boron and vitamin C attenuated MetHb formation, with the maximum effect achieved at 0.08mg/L and 10mg/L, respectively. Moreover, when these doses were used at different time intervals, a maximum effect was achieved when added 10 min before nitrite. The in vivo results demonstrated a significant reduction in methemoglobin formation in rats treated with boron and vitamin C alone. The hematological markers were not changed except for the platelet levels, which increased in the boron-treated and combination groups. The monocyte-to-lymphocyte ratio decreased significantly in all treatment groups compared with the positive control group. Conclusion: Boron protects against Hb oxidation induced by nitrite, and a potentiated effect has been achieved with the combination of vitamin C.

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The Effect of Borax on Hematological Parameters and Immunoglobulin Values in Rats

Cited by 2 publications

References 7 publications

Effect of boron on some organs of pregnant BALB/c mice

Effect of boron on some organs of pregnant BALB/c mice

Free Radical Scavenging Activity of Boron and Vitamin C in Nitrite-Induced Hemoglobin Oxidation Model: In vitro and in vivo Studies

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