Oral involvement in mycosis fungoides is unusual and portends a poor prognosis. The clinical findings of three new cases are described along with a differential diagnosis and review of the literature. For brevity, only one patient is discussed in detail below whereas the other two cases are solely described in table form. The patient had a four-year history of mycosis fungoides before developing an exophytic tongue tumor. He was treated with local electron beam radiation and is disease-free to date while being on maintenance therapy with oral bexarotene. Analysis of the data collected from our review of the literature and the present cases reveal key insights.
A 27-year-old man with a history of atopic dermatitis presented with asymptomatic bumps on the right third finger of several years' duration. He noted occasional trauma to the hands, including an incident to the affected finger requiring surgical repair. Physical examination revealed 15 to 20 firm, nontender, subcutaneous papulonodules on the right third digit, mostly on the dorsal and lateral aspects, without any apparent epidermal change. A 4-mm punch biopsy of a representative nodule was performed. THE BEST DIAGNOSIS IS: a. epithelioid sarcoma b. necrobiosis lipoidica c. rheumatoid nodule d. subcutaneous granuloma annulare e. tophaceous gout
2.Zwald FO, Brown M. Skin cancer in solid organ transplant recipients: advances in therapy and management, part I: epidemiology of skin cancer in solid organ transplant recipients.
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