Multiple Nontender Subcutaneous Nodules on the Finger

Abstract

A 27-year-old man with a history of atopic dermatitis presented with asymptomatic bumps on the right third finger of several years' duration. He noted occasional trauma to the hands, including an incident to the affected finger requiring surgical repair. Physical examination revealed 15 to 20 firm, nontender, subcutaneous papulonodules on the right third digit, mostly on the dorsal and lateral aspects, without any apparent epidermal change. A 4-mm punch biopsy of a representative nodule was performed. THE BEST DIAGNOSIS IS: a. epithelioid sarcoma b. necrobiosis lipoidica c. rheumatoid nodule d. subcutaneous granuloma annulare e. tophaceous gout

Primary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report

“…Due to amyloid in ltration in blood vessel walls, skin manifestations of PSA tend to be vascular, with petechia, purpura, ecchymosis, or nonhealing ulcers [4]. Pinch purpura, which often occurs in the periorbital region after minor trauma, is a characteristic skin manifestation of PSA [5]. Other skin manifestations include smooth, waxy, yellowish nodules, plaques, and scleroderma, which result from amyloid deposition in the dermis.…”