No abstract

No abstract

The aims of this study were to measure the levels of interleukin-33 (IL-33) and soluble Suppression of Tumorigenicity 2 (sST2) in patients with newly diagnosed primary hypertension (HT) and to determine the relationship between carotid intima-media thickness (CIMT) and IL-33/sST2. Eighty-two patients with newly diagnosed primary HT and ninety healthy volunteers were included in the study. CIMT ⩾0.9 mm was considered as significant for subclinical atherosclerosis. The sST2 levels of patients with primary HT were higher than those of the control group, whereas the IL-33 levels of these patients were much lower than those of the control group. The sST2 levels were higher in patients with subclinical atherosclerosis than in control subjects or patients with primary HT but not with subclinical atherosclerosis. In the primary HT group, sST2 had a positive correlation with CIMT, 24-h systolic-diastolic blood pressure, low-density lipoprotein and C-reactive protein, whereas sST2 had a negative correlation with the IL-33 level. A stepwise multivariable logistic regression analysis revealed that sST2 is an independent risk factor for subclinical atherosclerosis. Although the diagnostic predictive value of HT risk was determined as >51.8 pg l(-1) in the receiver operating characteristic curve analysis in respect of the sST2 level, the diagnostic predictive value for subclinical atherosclerosis risk was determined to be >107.2 pg l(-1). The sST2 level displays a positive correlation with atherosclerotic changes, and is an independent risk factor for subclinical atherosclerosis expressed as increased CIMT.

Based on these results, it could be said that oxidative stress, and therefore the ADMA level, could have an effect on the etiopathogenesis of MHT.

Objective: Obesity is a major modifiable risk factor for atherosclerosis. Thus, early risk markers are needed to identify obese subjects. The objective of this study was to examine the relationship between body composition and arterial stiffness documented by Doppler-derived renal resistive index (RRI). Subjects and methods: We enrolled 120 newly-diagnosed hypertensive patients (mean age 45 ± 8 years) who were admitted to our Nephrology Clinic. Body fat percentage (BFP) was measured by bioelectrical impedance (BIA). Doppler examinations were performed and RRI was calculated for all participants. Results: The female patients had higher RRI than male patients (0.69 vs 0.65, p ≤ 0.05). The study patients were divided into three groups according to their BFP defined by BIA. Group three patients, who exhibited higher body fat, had significantly higher body mass index [BMI] (p < 0.05), total leukocyte count (p < 0.05), C-reactive protein [CRP] (p < 0.05), triglyceride (p < 0.05), and female predominance. Group 3 patients were statistically older than Group 1 patients (46.2 vs 40.6 years, p < 0.05). Additionally, RRI levels were higher in Group 3 than in Group 1 [0.69 vs 0.65, p < 0.05] (Table 3). In logistic regression analysis, independent factors affecting RRI were age, gender, BFP and CRP levels (all p-values were < 0.05). Conclusions: Body fat percentage was associated with higher RRI, in hypertensive patients. Altered renal haemodynamic profile is involved in the long-term renal risk associated with body fat distribution.