Are increased oxidative stress and asymmetric dimethylarginine levels associated with masked hypertension?

Inan, Bayram; Ateş, İhsan; Ozkayar, Nihal; Kundi, Harun; Topçuoğlu, Canan; Dede, Fatih; Sennaroğlu, Engın

doi:10.3109/10641963.2015.1089883

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…However, it is unknown if they can detect early subtle changes of endothelial function. Only 2 small studies have found elevated plasma ADMA levels in white‐coat and masked hypertensives without comorbidities. To our knowledge, there is no previous study measuring ADMA levels simultaneously in all hypertension phenotypes.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports point toward a prominent vascular dysfunction in patients with masked hypertension (MH) and white‐coat hypertension (WCH) compared to normotensive individuals (NT) . Nevertheless, studies on endothelial function markers and their association with macrovascular damage across different hypertension phenotypes are limited …”

Section: Introductionmentioning

confidence: 99%

“…2,3 Nevertheless, studies on endothelial function markers and their association with macrovascular damage across different hypertension phenotypes are limited. 4 Arterial stiffness has been established as the major macrovascular damage seen in hypertension even from the very early stages. Pulse wave velocity (PWV) and central hemodynamics [central systolic blood pressure (cSBP), central diastolic blood pressure (cDBP), and central pulse pressure (cPP)] are considered the most robust markers of arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

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Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes

Gkaliagkousi

Triantafyllou

Nikolaidou

et al. 2018

J of Clinical Hypertension

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Essential hypertension (EH) represents a major public health problem having an increased incidence of cardiovascular events, mainly stroke and coronary heart disease. Micro-and macrovascular dysfunction contributes to the development of clinically detectable cardiovascular complications in hypertension. Despite a growing body of evidence in the field, the role of vascular dysfunction in the pathophysiology of EH remains under investigation.Recognition of different hypertension phenotypes is currently considered important in the diagnosis and management of hypertension.1 Several reports point toward a prominent vascular dysfunction in patients with masked hypertension (MH) and white-coat hypertension (WCH) compared to normotensive individuals (NT). (r = .156, P = .006), aortic pulse pressure (r = .153, P = .007) and marginally with carotidfemoral pulse wave velocity (r = .110, P = .051), as well as with diastolic office BP. In the multivariate model, aortic AIx75 and age were the only statistically significant predictors of ADMA. This is the largest study to document an independent association between ADMA and aortic AIx75 but not with other indices of arterial stiffness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes

Gkaliagkousi

Triantafyllou

Nikolaidou

et al. 2018

J of Clinical Hypertension

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“…Nitric oxide deficiency as well as oxidative stress play an important role in arterial hypertension. Likewise, numerous investigations have shown a link between ADMA levels and the occurrence and development of hypertension [60][61][62]. Controversially, there are also studies in the general population which could not prove this association [63].…”

Section: Adma and Sdma In Relation To Vascular Risk Factorsmentioning

confidence: 99%

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

Große

Schwedhelm

Worthmann

et al. 2020

IJMS

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The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

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“…Коэффициенты корреляции для указанных пар показателей составили r=0,416 и r=0,409 соответственно (p<0,05). Полученные в нашем ис-следовании результаты свидетельствуют о том, что при контролируемой АГ на скорость развития ЭД влияют нарушения углеводного и липидного обмена, что в значительной мере согласуется с сообщениями других авторов [14]. Другие параметры липидного профиля во II группе, как и в I группе, не связаны с уровнем ADMA (p>0,05; табл.…”

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Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension

Подзолков

Иванович²,

Сафронова

et al. 2019

Terapevticheskii arkhiv

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Aim. To conduct a comparative analysis of the level of asymmetric dimethylarginine (ADMA) in two groups of patients with a diagnosis of essential arterial hypertension (AH). Group I - patients with uncontrolled hypertension (UCAH) and group II - patients with controlled course of hypertension (CAH). Materials and methods. The study included 109 patients: group I - 73 patients with UCAH, group II - 36 patients with CAH. Groups were comparable. Clinical, laboratory and instrumental examination was performed, including determination of ADMA concentration in blood plasma. Results. The concentration of ADMA in patients with UCAH was significantly higher than in the group with CAH. In patients with UCAH, a pronounced positive correlation was found between the concentration of ADMA and creatinine level (r=0.615, p

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Are increased oxidative stress and asymmetric dimethylarginine levels associated with masked hypertension?

Abstract: Based on these results, it could be said that oxidative stress, and therefore the ADMA level, could have an effect on the etiopathogenesis of MHT.

Cited by 11 publications

References 21 publications

Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes

Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension

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