How does thiol/disulfide homeostasis change in prediabetic patients?

Ateş, İhsan; Kaplan, Mustafa; Inan, Bayram; Alışık, Murat; Erel, Özcan; Yılmaz, Nisbet; Güler, Serdar

doi:10.1016/j.diabres.2015.09.011

Cited by 61 publications

(48 citation statements)

References 28 publications

(36 reference statements)

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“…Thiol/disulfit homeostazı (TDH) anti-oksidan korunma, detoksifikasyon, hücre büyümesi ve aopopitozu gibi birçok hücresel aktivitede kritik role sahiptir (10,11) . Daha önceleri prediabet, otoimmün subklinik hipotiroidizm (Hashimoto tiroiditi), polikistik over sendromu, Kırım Kongo hemorajik ateşi, ani sensorinöral işitme kaybı, prematür ovariyan yetmezlik gibi birçak farklı hastalıkta TDH'nın etyopatogenetik rolü araştırılmıştır (12)(13)(14)(15) . Bu homeostazın immün etyopatogenezde çok önemli rol oynadığı ve TDH'ındaki dengesizliğin oksidatif stres ve doku inflamasyonu aracılığıyla hastalığı tetiklediği düşünülmektedir.…”

Section: Introductionunclassified

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Üstüner¹

2017

IKSST

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Section: Introductionunclassified

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Üstüner¹

2017

IKSST

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“…This show us that oxidative stress may increase with age [23] and disulphide/thiol homeostasis may shift towards disulphide. Further studies have confirmed the positive correlation between oxidative stress and age; while a negative correlation between native thiol level and both age and BMI has been determined [13]. As stated in the "Study subjects" section, the controls and study group were matched for age and BMI, hence the correlation of thiol levels with BMI and age could not be carried out.…”

Section: Discussionmentioning

confidence: 95%

“…Glutathione (GSH) level was found lower in PC patients compared with the controls [12]. Only a small thiol fraction is found among low molecular weight compounds, such as cysteine (Cys), cysteinylglycine, GSH, homocysteine and c-glutamylcysteine; the main part is found in albumin and other plasma proteins [13,14].…”

Section: Discussionmentioning

confidence: 99%

Dynamic thiol/disulphide homeostasis before and after radical prostatectomy in patients with prostate cancer

Hanikoglu¹,

Hanikoğlu

Kucuksayan

et al. 2016

Free Radical Research

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Thiol groups are important anti-oxidants and essential molecules protecting organism against the harmful effects of reactive oxygen species (ROS). The aim of our study is to evaluate thiol-disulphide homeostasis with a novel recent automated method in patients with localized prostate cancer (PC) before and six months after radical prostatectomy (RP). 18 patients with PC and 17 healthy control subjects were enrolled into the study. Blood samples were collected from the controls subjects and patients before and six months after RP. Thiol-disulphide homeostasis was determined using a recently developed novel method. Prostate-specific antigen (PSA), albumin, total protein, total thiol, native thiol, disulphide and total antioxidant status (TAS) were measured and compared between the groups. Native thiol, total thiol and TAS levels were significantly higher in the control group than the patients before RP (p < .001). There was a non-significant increase in the native thiol, total thiol and TAS levels in the patients six months after RP in comparison to the levels before RP (p values .3, .3 and .09, respectively). We found a significant negative correlation between PSA and thiol levels. Our study demonstrated that the decreased thiol and TAS levels weakened anti-oxidant defence mechanism in the patients with PC as indicated. Increased oxidative stress in prostate cancer patients may cause metabolic disturbance and have a role in the aetiopathogenesis of prostate cancer. ARTICLE HISTORY

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“…Exchanges in thiol-disulfide homeostasis are key in antioxidant protection, detoxification, organization of enzymatic activity, and parts of cellular signaling mechanism (10,11). Thiol-disulfide homeostasis is linked to many disorders such as diabetes mellitus, cancer, migraine, hyperemesis gravidarum, and chronic renal impairment (14)(15)(16)(17). Cysteine and cysteine components are the main thiol-disulfide structures.…”

Section: Discussionmentioning

confidence: 99%

Thiol–disulfide Homeostasis in Acute Appendicitis

Yüzbaşıoğlu¹,

Haydar²,

Otal³

et al. 2017

Med J Islamic World Acad Sci

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SUMMARYThis study aimed to assess the diagnostic value of thiol-disulfide homeostasis in patients with acute appendicitis (AA).A total of 43 patients diagnosed with acute appendicitis in the emergency department and 59 healthy individuals were evaluated. Age, gender, white blood cell count, and thiol-disulfide homeostasis parameters (native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios) were compared between groups.Thiol-disulfide homeostasis was determined using a newly developed method by Erel and Neşelioğlu. White blood cell counts were statistically significantly higher in the AA group, but no significant difference (P = 0.742) was found between native thiol, total thiol, and disulfide levels of the patient and control groups. Also, no statistically significant difference was observed in disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios (P = 0.117) between groups.This was thought to be a result of early diagnosis of AA in patients at the emergency department. Hence, the inflammatory response did not increase significantly at the time of diagnosis.

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How does thiol/disulfide homeostasis change in prediabetic patients?

Cited by 61 publications

References 28 publications

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Thiol/disulfide homeostasis as a novel inflammatory marker in vitiligo

Dynamic thiol/disulphide homeostasis before and after radical prostatectomy in patients with prostate cancer

Thiol–disulfide Homeostasis in Acute Appendicitis

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