Five metal complexes with Schiff-base ligand, 3-((4-phenylthiazol-2-ylimino) methyl)-2-hydroxybenzoic acid were synthesized with metal ions such as Cu(II), Co(II), Ni(II), Cd(II) and Zn(II). The reaction likely proceeds via condensation of 2-amino-4-phenyl thiazole with 3-aldehydosalicylic acid and characterized by elemental analysis and various spectral studies like FT-IR, 1 H NMR, ESI mass, and TGA/TDA and molar conductance studies. The spectral results revealed bidentate O-O donor and forms the complexes having square planar geometry. The antibacterial and antifungal activity of the ligand and its metal complexes was found based on the determination of minimum inhibitory concentrations. The brine shrimp biological assay was also carry out to study the In vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. Moreover, DNA cleavage experiments revealed that the Cu (II), Co (II) and Zn (II) complexes exhibited remarkable DNA cleavage activities via the generation of hydroxyl radical.
Levels of chemical parameters (pH, EC, Na & Ca), Major nutrients (Organic Carbon, Available Nitrogen, Phosphorous and Potassium) and Micro nutrients ( Fe, Mn, Zn, Cu, Boron and Molybdenum)
Objective:The main aim of the present work was to synthesize a novel Schiff base ligand 2-hydroxy-3-((4-(4-phenylthiazol-2-yl) semicarbazide) methyl) benzoic acid is obtained by the condensation of N-(4-phenylthiazole-2-yl) hydrazine carboxamide with 3-Aldehydosalicylic acid and its Cu(II), Co(II), Ni(II), and Zn(II) complexes and study of their biological activity. Methods: The compounds are characterized by elemental analysis and various physicochemical techniques like IR, 1 H NMR, ESI-mass, and molar conductance data. All the compounds were screened for their antibacterial and antifungal activity by MIC method. Further, to study the in vitro cytotoxicity properties of all the compounds against Artemia salina and DNA cleavage activity by Agarose Gel Electrophoresis (AGE) method. Results: Spectral investigations suggested square pyramidal coordination geometrical arrangement for all the metal (II) complexes, having 1:1 stoichiometric ratio of the type [ML (Cl) 2 ]. The antimicrobial activity results revealed that the metal complexes were found to be more active than the free ligand. Furthermore, the DNA cleavage activity of the compounds on plasmid DNA pBR322 molecule showed moderate activity.
Conclusion:The newly synthesized ligand acts as OON donor tridentate chelate and coordinated through an oxygen of azomethine nitrogen, Phenolic OH and Carboxylic acid (COOH) of 3-Aldehydosalicylic acid to the Cu, Co, Ni and Zn metal ions and form square pyramidal geometrical arrangement. All the complexes are found to be non-electrolytic in nature. Further, all the newly prepared compounds showed moderate biological activity.
Physico-Chemical analysis of ground water samples was carried out from 20 locations of Bagalkot, Badami and Hungund and Ilkal taluks. The analysis of different parameters such as Temperature, pH, EC, TDS and Fluoride were carried out as per the standard methods. All the parameters studied were within the permissible limit except Fluoride content in few locations. The analyzed results indicate the Fluoride concentration in some sampling spots namely Simikeri (Govt. Primary School Campus) of Baglkot Taluk, Maradi village and Budanagad village of Badami Taluk, Yarigonal village, Ilkal (Near Municipalty) and Aminagad (Gudur Cross) of Hungund taluk were found above standards probably due to seasonal variations and salt water contamination. Fluoride ion in water sources is known for both beneficial and detrimental effects on live stock. The higher concentration of Fluoride in ground water causes a disease called "Fluorosis". It is a slow, progressive, crippling malady, which affects every organ, tissue and cells in the body and results in health complaints having overlapping manifestations with several other diseases like chronic dental and skeletal Fluorosis.
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