In the present work, poly(vinyl alcohol)/Syzygium cumini leaves extract (PSN) and poly(vinyl alcohol)/chitosan/S. cumini leaves extract blend films were prepared by solution casting technique. The films were characterized by using scanning electron microscopy, atomic force microscopy, X-ray diffraction study, Fourier transform infrared spectroscopy, thermogravimetric analysis, and universal testing machine. The results indicated that the appreciable physical interaction at lower concentrations of S. cumini leaves extract in the PVA and PVA/chitosan films contribute to the smooth uniform morphology, increased the degree of crystallinity, degradation temperature, and improved mechanical properties. Further, films were analyzed with water contact angle analyzer which illustrates that blend films were hydrophilic (PSN-1) and hydrophobic (PCS-1) in nature. However, blend films were also subjected to the antimicrobial study, which revealed that inclusion of S. cumini leaves extracts significantly enhanced the antibacterial activity in the PVA and PVA/chitosan film. With all of these results, fabricated blends can find potential applications in packaging material to extend the shelf life of foodstuffs.

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The present work reports the design, synthesis, characterization and antibacterial screening of novel aminothiazole derivatives as FabH inhibitor [β-ketoacyl-ACP synthase (KAS)] which plays major role in bacterial cell wall construction. The compound 5d had crystallized in monoclinic, P21/c space group which was determined by single-crystal X-ray crystallography. In vitro antibacterial activity studies were carried out on S. aureus (MCC 2043), E. faecalis (MTCC 2729), E. coli MTCC443 and C. violaceus (MCC 2216). Most of the compounds showed potent inhibition activity against Gram-negative bacteria than Gram-positive bacteria. Compound 5a showed the highest zone of inhibition of 16 mm and MIC value of 5.33 μM which is comparable to that of the standard antibiotic, streptomycin. This result was ably complimented by in silico studies where compound 5a exhibited high affinity, strong binding energy and docking score of 6.214 kcal mol −1. The most potent compounds were nonhemolytic and nontoxic to mammalian cells.

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