The study explores the one-pot synthesis of novel α-aminonitriles by reacting 4-[(1H-benzimidazol-2-yl)methoxy]benzaldehyde, substituted anilines and sodium cyanide using a catalytic amount of copper dipyridine dichloride (CuPy Cl ) and employing the Strecker reaction under mild conditions. All the synthesized compounds were screened for antimicrobial and antitubercular activity. The promising lead compounds 4d and 4e were identified, with MIC values ranging between 3.9 and 7.8 µg/mL against different bacterial strains. Compounds 4c-e and 4g also showed good antifungal activities against the tested fungal strain. Among those tested, compound 4e exhibited excellent antitubercular activity (MIC 0.05 μg/mL) with a low level of cytotoxicity, suggesting that compound 4e is a promising lead for subsequent investigations in search for new antitubercular agents.

Five metal complexes with Schiff-base ligand, 3-((4-phenylthiazol-2-ylimino) methyl)-2-hydroxybenzoic acid were synthesized with metal ions such as Cu(II), Co(II), Ni(II), Cd(II) and Zn(II). The reaction likely proceeds via condensation of 2-amino-4-phenyl thiazole with 3-aldehydosalicylic acid and characterized by elemental analysis and various spectral studies like FT-IR, 1 H NMR, ESI mass, and TGA/TDA and molar conductance studies. The spectral results revealed bidentate O-O donor and forms the complexes having square planar geometry. The antibacterial and antifungal activity of the ligand and its metal complexes was found based on the determination of minimum inhibitory concentrations. The brine shrimp biological assay was also carry out to study the In vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. Moreover, DNA cleavage experiments revealed that the Cu (II), Co (II) and Zn (II) complexes exhibited remarkable DNA cleavage activities via the generation of hydroxyl radical.

In search of pharmacologically active potent compounds, a series of carbonyl-amide linkage based new benzimidazole derivatives were synthesized from acid, aldehydes and isocyanide at ambient temperature via Passerini reaction. All the compounds synthesized were screened for their potential anti-inflammatory, antidiabetic and anticonvulsant properties. The results revealed that compounds 2i and 2j were found to be the most potent anti-inflammatory agents, while compounds 2a, 2c, 2e, 2f, 2i and 2j showed increased antidiabetic activity than the reference drugs and 2a, 2g, 2h, 2i and 2j were found to be the main structural requirement for maintaining anticonvulsant activity.

Porous Tin Oxide (SnO 2) thin films have been prepared using Chemical Spray Pyrolysis technique in conjunction with surfactant Triton X-100. The effect of surfactant on the gas sensing properties of SnO 2 have been investigated using characterization techniques, XRD, SEM, EDAX, UV-Visible spectroscopy. SnO 2-Surfactant composite films were deposited by adding Triton X-100 in step of 1%, 2%, 3%, 4%, 5%, and 6% to the precursor solution of SnCl 4 in Ethanol. The results reveal the successful enhancement of gas sensitivity of SnO 2-Triton X-100 composite thin films as compared with pristine SnO 2. Films of SnO 2 with 4% Triton X-100 have exhibited maximum sensitivity for H 2 S gas, whereas the films with less and more than 4% Triton X-100 has shown less sensitivity. Thus, the percentage of Triton X-100 has been optimized to achieve maximum sensitivity.

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