Male vollunteers performed four memory tasks either while sober or lunder effects of alcohol. Twenty-four hours later they were tested under the same or different conditions. In tasks measuiring recall and interference, learning transfer was better when the subject was intoxicated during both sessions than when he was intoxicated only during the learning session. In a task measuring recognition, transfer was not significantly affected by changing state. Thus, alcohol appears to produce "dissociated" or state-dependent effects in man, but not all forms of memory are equally sensitive to the phenomenon.
In this prospective, 1-year study, 360 males admitted to an inpatient alcoholism treatment program were administered a DSM-III compatible structured interview and subtyped by co-occurring psychiatric disorder. Forty percent satisfied diagnostic criteria for alcohol dependence while 27% met criteria for alcohol dependence and one additional psychiatric syndrome. The dually diagnosed patients were divided into: alcohol dependence plus drug abuse, alcohol dependence plus antisocial personality and alcohol dependence plus depression. These subtypes were compared on multiple dimensions at intake and at 1-year follow-up. At follow-up, all groups showed significant improvement in drinking and psychosocial functioning. The results suggest that subtyping alcoholics by co-morbid psychiatric disorders may be a good postdictor of clinical history, but a poor predictor of drinking outcome.
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