Abstract:In this prospective, 1-year study, 360 males admitted to an inpatient alcoholism treatment program were administered a DSM-III compatible structured interview and subtyped by co-occurring psychiatric disorder. Forty percent satisfied diagnostic criteria for alcohol dependence while 27% met criteria for alcohol dependence and one additional psychiatric syndrome. The dually diagnosed patients were divided into: alcohol dependence plus drug abuse, alcohol dependence plus antisocial personality and alcohol depende… Show more
“…The Childhood Deviance Scale correlated signifi cantly with comparable items collected 10 or 20 years earlier, such as the Childhood Conduct Disorder Scale (r = .56, p < .0001) and the School Teacher Questionnaire Behavioral Summary Score (r = .37, p < .0001) (Knop et al, 2009). The Psychosocial Interview also collected extensive data about the quantity and frequency of the consumption of beer, wine, and distilled spirits in the recent past and included the 32-item Alcoholism Severity Scale used in other studies by our group (Penick et al, 1987;Powell et al, 1992) to evaluate the major symptoms of alcoholic drinking both in the past year and over the subject's lifetime.…”
ABSTRACT. Objective: In a search for viable endophenotypes of alcoholism, this longitudinal study attempted to identify premorbid predictors of alcohol dependence that also predicted the course of alcoholism. Method: The 202 male subjects who completed a 40-year follow-up were originally selected from a Danish birth cohort (N = 9,182). Two thirds of the subjects were high-risk biological sons of treated alcoholics. A large number of measures (361) were obtained at different periods before any subject had developed an alcohol-use disorder. At age 40, a psychiatrist provided mutually exclusive lifetime diagnoses of alcohol abuse or alcohol dependence that were characterized as currently active or currently in remission according to Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, course specifi ers. Results: The majority of subjects with a diagnosis of alcohol abuse were in remission at age 40 compared with those with a diagnosis of alcohol dependence (88% vs. 58%). Treatment did not predict remission. Fourteen of the 18 predictors of remission that also predicted dependence were submitted to an exploratory factor analysis (varimax). Two premorbid dimensions were identifi ed: cognitive effi ciency and early behavioral dyscontrol in childhood. Both factors predicted the failure to remit (low cognitive effi ciency and high behavioral dyscontrol) even when lifetime alcoholism severity was controlled. Conclusions: This 4-decade study found a striking disconnect between measures that predicted alcohol dependence and measures that predicted remission from alcohol dependence. I N THE LAST 60 YEARS, prospective longitudinal studies have attempted to identify the premorbid antecedents of the alcohol-use disorders, especially alcohol dependence, by examining subjects before drinking problems began and following them into adulthood (Goodwin et al., 1994;Hill et al., 2000;Knop et al., 2003;Trim et al., 2010;Vaillant, 1995Vaillant, , 2003Zucker, 2006). The number of premorbid research domains that have been investigated is quite large and range from genetic, family history, and developmental domains through personality, social, and behavioral domains, to cultural and social context domains. These longitudinal studies have produced lists of replicated risk factors that are thought to function as premorbid predictors or markers of alcoholism. Among the best established of these premorbid risk factors are family history of alcoholism; male gender; behavioral deviance of all sorts in early childhood, especially that associated with impulsivity; unstable family environment; lower social class; high "innate" tolerance to the effects of alcohol; early age at onset of problem drinking; and peer pressure.It is frequently assumed that risk factors known to increase the probability of developing an alcohol-use disorder are the same as those that interfere with or impede the recovery from alcoholic drinking. Despite the seemingly reasonable assumption that premorbid risk factors also predict the course of alc...
“…The Childhood Deviance Scale correlated signifi cantly with comparable items collected 10 or 20 years earlier, such as the Childhood Conduct Disorder Scale (r = .56, p < .0001) and the School Teacher Questionnaire Behavioral Summary Score (r = .37, p < .0001) (Knop et al, 2009). The Psychosocial Interview also collected extensive data about the quantity and frequency of the consumption of beer, wine, and distilled spirits in the recent past and included the 32-item Alcoholism Severity Scale used in other studies by our group (Penick et al, 1987;Powell et al, 1992) to evaluate the major symptoms of alcoholic drinking both in the past year and over the subject's lifetime.…”
ABSTRACT. Objective: In a search for viable endophenotypes of alcoholism, this longitudinal study attempted to identify premorbid predictors of alcohol dependence that also predicted the course of alcoholism. Method: The 202 male subjects who completed a 40-year follow-up were originally selected from a Danish birth cohort (N = 9,182). Two thirds of the subjects were high-risk biological sons of treated alcoholics. A large number of measures (361) were obtained at different periods before any subject had developed an alcohol-use disorder. At age 40, a psychiatrist provided mutually exclusive lifetime diagnoses of alcohol abuse or alcohol dependence that were characterized as currently active or currently in remission according to Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, course specifi ers. Results: The majority of subjects with a diagnosis of alcohol abuse were in remission at age 40 compared with those with a diagnosis of alcohol dependence (88% vs. 58%). Treatment did not predict remission. Fourteen of the 18 predictors of remission that also predicted dependence were submitted to an exploratory factor analysis (varimax). Two premorbid dimensions were identifi ed: cognitive effi ciency and early behavioral dyscontrol in childhood. Both factors predicted the failure to remit (low cognitive effi ciency and high behavioral dyscontrol) even when lifetime alcoholism severity was controlled. Conclusions: This 4-decade study found a striking disconnect between measures that predicted alcohol dependence and measures that predicted remission from alcohol dependence. I N THE LAST 60 YEARS, prospective longitudinal studies have attempted to identify the premorbid antecedents of the alcohol-use disorders, especially alcohol dependence, by examining subjects before drinking problems began and following them into adulthood (Goodwin et al., 1994;Hill et al., 2000;Knop et al., 2003;Trim et al., 2010;Vaillant, 1995Vaillant, , 2003Zucker, 2006). The number of premorbid research domains that have been investigated is quite large and range from genetic, family history, and developmental domains through personality, social, and behavioral domains, to cultural and social context domains. These longitudinal studies have produced lists of replicated risk factors that are thought to function as premorbid predictors or markers of alcoholism. Among the best established of these premorbid risk factors are family history of alcoholism; male gender; behavioral deviance of all sorts in early childhood, especially that associated with impulsivity; unstable family environment; lower social class; high "innate" tolerance to the effects of alcohol; early age at onset of problem drinking; and peer pressure.It is frequently assumed that risk factors known to increase the probability of developing an alcohol-use disorder are the same as those that interfere with or impede the recovery from alcoholic drinking. Despite the seemingly reasonable assumption that premorbid risk factors also predict the course of alc...
“…Others question the overall relevance of subgroups, believing that high levels of psychiatric symptoms are inherent in alcohol-dependent individuals, even when sober (28). Yet other research challenges the belief that affective disturbances of any type are related to the clinical outcome, and there are disagreements about the optimal way to identify and characterize potentially substanceinduced disorders (26,(29)(30)(31).…”
“…In one of the Indian studies (26), it was reported that substance use is confined to tribal females, those of lower socio-economic status. Other studies too have reported their patient population as belonging to lower middle and lower class and being employed (17,18). The majority of female patients in the current study belonged to the lower socio-economic class (68%), rural background (62%), and worked as daily wage laborers (64%) either in factories or agricultural fields.…”
Section: Discussionmentioning
confidence: 53%
“…Mean age at presentation in various studies have ranged between 35 and 46 years (15)(16)(17)(18). Two earlier studies (19,20) usually in their fourth decade of life and later compared to males.…”
Background: In the recent decades, increasing number of females have been seeking de-addiction services yet data in this regard is very limited from across the globe as well as from India. Objectives: The aim of this research was to study the gender differences in demographic and clinical profile and psychiatric comorbidity among patients with alcohol dependence syndrome (ADS). Methods: This cross sectional study was conducted at Shridevi Institute of Medical Sciences and Research Hospital, a tertiary care center located in Tumkur, India, during year 2015 to 2016. Seventy male and 50 female subjects (aged 18 to 50 years) meeting the criteria for ADS, were assessed using socio-demographic and clinical proforma, severity of alcohol dependence questionnaire (SADQ), and mini international neuropsychiatric interview (MINI).
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