As the number of COVID-19 cases increasing, more and more patients are concerning about alopecia, a sequela after SARS-CoV-2 infection. We here report a case of a 38-year-old woman with a typical acute telogen effluvium (ATE) after recovery from COVID-19.
Rationale:
Giant keloids often have indications for surgical resection, but postoperative reconstruction of the skin and high recurrence of keloids are a challenge for clinical treatment. This article reports a rare successful treatment of a giant keloid in the anterior chest wall by multistage surgery combined with radiotherapy, which is why this case is meaningful.
Patient concerns:
A 66-year-old woman presented a giant keloid with ulcerations and severe itching on the anterior chest wall. She had a history of keloid disease for more than 10 years, and had been treated by multiple operations, with no success.
Diagnoses:
The patient was diagnosed as keloid based on her history and symptoms. Histopathology findings supported our diagnosis.
Interventions:
We successfully excised the keloid after 5 operations and 2 rounds of electron-beam radiotherapy, which was applied at 24 hours after the 4th and 5th operation.
Outcomes:
There was no sign of recurrence over the follow-up period of 24 months.
Lessons:
The combination of multistage surgery and radiotherapy presents as a good choice for the treatment of giant keloids.
Background
Mutation in the lipase H (LIPH) gene is a main reason for autosomal recessive woolly hair (ARWH)/hypotrichosis. Although some studies reported that topical minoxidil could improve ARWH, an effective treatment method for this disease is still lacking.
Aim
We attempt to explore potential treatment options for ARWH.
Materials & Methods
A female 6‐year‐old child was diagnosed with ARWH/hypotrichosis caused by LIPH mutations. And she was treated with combined treatment of botanical extracts.
Results
After 6 months of treatment, the patient's hair grew remarkably. After 4 years of treatment, the patient's hair remained dense.
Discussion
After the combination treatment, the patient saw a favorable clinical effect. However, the specific mechanisms of action for botanical extracts require further validation. In addition, some regenerative strategies may be considered as potential treatment options for ARWH. We should actively attempt treatment for ARWH patients and encourage prenatal diagnosis due to the great impact of hair loss.
Conclusion
The combined therapy of botanical extracts may improve ARWH long‐term with a sustainable therapeutic effect.
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