Multi-stage surgery combined with radiotherapy for treatment of giant anterior chest wall keloid

Liu, Qingwu; Li, Ping; Yang, Zhiyong; Qu, Baoquan; Qin, Chunfang; Meng, Shengnan; Fang, Huijuan; Wu, Ruiying; Cheng, Tiantian; Yang, Dingquan

doi:10.1097/md.0000000000018886

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Keloids are common in African, Spanish, and Asian populations, with an incidence ranging from 4.5 to 16%, and cause itching, pain, and a burning sensation (Niessen et al, 1999). Keloids can occur within years, and more likely after an inciting stimulus such as dermal injury or an inflammatory process (Limandjaja et al, 2020); however, they are most often found on the chest, shoulders, upper back, and back of the neck, where skin tension is higher than in other areas of the body (Ogawa et al, 2012;Liu et al, 2020). In addition, keloids tend to occur on the earlobes as a result of ear piercing, burns, or surgical procedures.…”

Section: Fibrosis Keloids and Hypertrophic Scarsmentioning

confidence: 99%

Primary Ciliary Signaling in the Skin—Contribution to Wound Healing and Scarring

Hosio

Jaks

Lagus

et al. 2020

Front. Cell Dev. Biol.

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Section: Fibrosis Keloids and Hypertrophic Scarsmentioning

confidence: 99%

Primary Ciliary Signaling in the Skin—Contribution to Wound Healing and Scarring

Hosio

Jaks

Lagus

et al. 2020

Front. Cell Dev. Biol.

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“…These neurotransmitters consist of histamine, acetylcholine, bradykinin, and proteinase. The itching sensation in the wound healing process is caused by an inflammatory response and partly due to the presence of mast cells in the wound area [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Association Between Sebum, Total Cholesterol, and Low-Density Lipoprotein (LDL) Cholesterol Levels With Post-acne Keloids

Kurniawati,

Rodian,

Argentina

et al. 2023

Cureus

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Background Prolonged acne inflammation causes scar formation, one of which is post-acne keloids. Sebum, total cholesterol, and low-density lipoprotein (LDL) level can influence post-acne keloids. This study aims to determine the association between sebum, total cholesterol, and LDL levels with post-acne keloids to better define the predisposing factors for this condition. Methods This study used primary data involving sociodemographics, clinical features, keloid classification, sebum levels, total cholesterol levels, and LDL levels in post-acne keloid patients at the Dermatology, Venereology, and Aesthetics Outpatient Clinics of Dr. Mohammad Hoesin General Hospital Palembang, Indonesia. Study samples were patients who fulfilled the inclusion and exclusion criteria by consecutive sampling. The data then underwent univariate and bivariate analyses to show the association between variables. Result A total of 22 patients with post-acne keloids participated. The subjects presented mostly with major keloids based on the classification (59.1%). The patients were predominantly 21-30 years old (50%) and male (90.9%). The keloids had onsets >six months to one year (45.5%), durations of one to five years (77.3%), and multiple presentations (68.2%). Vancouver Scar Scale (VSS) assessment showed mainly red vascularity (40.9%), mixed pigmentation (68.2%), >5 mm keloid height (59.1%), and firm pliability (40.9%). Most patients presented with pruritus (86.4%) but without pain (54.5%). Most had low levels of sebum (50%), normal total cholesterol (90.9%), and near-optimal LDL level (40.9%). There were no significant association between sebum (p = 1.000), total cholesterol (p = 1.000), and LDL (p = 0.376) levels with post-acne keloids. However, LDL levels above normal were most found in this study (68.2%). Conclusions There is no association between sebum, total cholesterol, and LDL levels with post-acne keloids. Despite the fact that LDL level was not statistically significant, there has been a rise in LDL level in the research subjects. Further research with a larger number of subjects and consideration of multicenter study through retrospective/prospective methods and complete lipid profile examinations is still required to provide a more representative study.

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Development of Postsurgical Pyoderma Gangrenosum with New Keloid after Keloid Resection

Saijo,

Kuwahara,

Ito

et al. 2024

Adv Skin Wound Care

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Keloids are a dermal fibroproliferative disorder and can arise from trauma, acne, vaccination, and herpes zoster. Pyoderma gangrenosum (PG) is a painful ulcerative skin disorder that is associated with neutrophilic dysfunction. However, the pathophysiologies of keloids and PG are not fully understood. The authors encountered an unusual case of a 24-year-old woman who presented with an anterior chest keloid that bore an ulcer. The keloid was resected along with the ulcer, and histology revealed the ulcer to be a neutrophilic PG ulcer. A year after surgery, another ulcer developed in the scar. The ulcer met the PARACELSUS criteria of a postsurgical PG ulcer. After treatment with systemic prednisone and adalimumab for 250 days, the ulcer re-epithelialized. However, relapsed keloids were then observed at the PG site. Corticosteroid taping may be the safest therapy for patients with a history of PG. Conversely, if there is suspicion that a patient is prone to keloid development, diagnostic biopsies and surgical management of PG ulcers should be avoided or conducted with care.

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Multi-stage surgery combined with radiotherapy for treatment of giant anterior chest wall keloid

Cited by 3 publications

References 23 publications

Primary Ciliary Signaling in the Skin—Contribution to Wound Healing and Scarring

Primary Ciliary Signaling in the Skin—Contribution to Wound Healing and Scarring

Association Between Sebum, Total Cholesterol, and Low-Density Lipoprotein (LDL) Cholesterol Levels With Post-acne Keloids

Development of Postsurgical Pyoderma Gangrenosum with New Keloid after Keloid Resection

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