Herein, we described a highly regio- and enantioselective Friedel–Crafts alkylation of aniline derivatives with in situ generated ortho-quinone methides enabled by chiral phosphoric acid, furnishing a wide range of enantioenriched triarylmethanes bearing three similar benzene rings in high yields (up to 98%) with excellent stereoselectivities (up to 98% ee). Furthermore, the large-scale reactions and diversified transformations of product demonstrate the practicality of the protocol. Density functional theory calculations elucidate the origin of the enantioselectivity.

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The live Lactobacillus acidophilus (La) alleviated colitis by ameliorating intestinal barrier and suppressing inflammation. SCFAs modulated and enriched by La promoted the mitophagy/NLRP3 inflammasome pathway, which helped to improve gut functions.

Lycorine-type alkaloids are privileged structures in the drug development due to its attractive biological activities. In this paper, the carbonyl on the C ring was proved to have played a...