Live <i>Lactobacillus acidophilus</i> alleviates ulcerative colitis <i>via</i> the SCFAs/mitophagy/NLRP3 inflammasome axis

Li, Pei; Chen, Guoping; Zhang, Jiaxian; Pei, Chaoying; Chen, Ying; Gong, Jing; Deng, Song; Cai, Kaiwei; Li, Haiyan; Wang, Dawei; Shen, Baochun; Xie, Zenghong; Liao, Qiongfeng

doi:10.1039/d1fo03360c

Cited by 33 publications

(23 citation statements)

References 46 publications

(44 reference statements)

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“…Among the various factors, the role of gut microbiota has received much attention 18 . Moreover, considerable evidence indicates that probiotics administration could attenuate UC-associated symptoms and inflammation, presumably through modulating the gut microbiota (Table 1) [19][20][21][22][23][24][25][26][27][28][29][30][31][32] . Meanwhile, emerging studies also reported that postbiotic application could reduce the risk of development of UC 31,[33][34][35][36] .…”

Section: Introductionmentioning

confidence: 99%

Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

Zhang

Feng

et al. 2022

npj Sci Food

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Probiotics are increasingly used as adjunctive therapy to manage gastrointestinal diseases, such as ulcerative colitis. However, probiotic use has posed some safety concerns. Thus, postbiotics are proposed as alternatives to probiotics in clinical applications. However, no study has directly compared the clinical benefits of probiotics and postbiotics. This study compared the beneficial effect of postbiotics and probiotics derived from the strain, Bifidobacterium adolescentis B8598, in a dextran sulfate sodium (DSS)-induced experimental colitis mouse model. Four groups of mice (n = 7 per group) were included in this work: Control (received water plus saline), DSS (received DSS without postbiotic/probiotic), Postbiotic (received DSS plus postbiotic), and Probiotic (received DSS plus probiotic). Our results showed that intragastric administration of both probiotic and postbiotic ameliorated colitis, reflected by decreased histology scores in Postbiotic and Probiotic groups compared with DSS group (P < 0.05). The fecal microbiota alpha diversity was not significantly affected by DSS-, postbiotic, or probiotic treatment. However, the postbiotic treatment showed stronger effects on modulating the fecal microbiota beta diversity, composition, and metagenomic potential than the probiotic treatment. Overall, our findings suggested that probiotics and postbiotics had similar ability to improve disease phenotype but had distinct ability to regulate the gut microbiota and metabolic pathways in the context of ulcerative colitis. In view of the smaller safety concern of postbiotics compared with probiotics and its stronger modulatory effect on the host gut microbiota, we propose that postbiotics are to be considered for use as next-generation biotherapeutics in managing ulcerative colitis or even other diseases.

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Section: Introductionmentioning

confidence: 99%

Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

Zhang

Feng

et al. 2022

npj Sci Food

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“…Although Lactobacillus cannot directly produce SCFAs, its metabolite lactic acid can be utilized by bacteria of all kinds, such as Clostridium propionicum, Propionibacterium, and many other bacteria to ferment acetic acid and propanoic acids (Li, Chen, et al, 2022;Sato et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…By lowering proinflammatory cytokine levels and regenerating intestinal epithelial cells, SCFAs have ameliorated colitis (Banskota et al., 2021; Parada Venegas et al., 2019). Although Lactobacillus cannot directly produce SCFAs, its metabolite lactic acid can be utilized by bacteria of all kinds, such as Clostridium propionicum, Propionibacterium , and many other bacteria to ferment acetic acid and propanoic acids (Li, Chen, et al., 2022; Sato et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

Egg white peptides administration in enhancing pathological immune response and regulating intestinal bacteria abundance: A new strategy for relieving young mice colitis

Yang

et al. 2023

Food Frontiers

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Ulcerative colitis (UC) threatens teenagers’ health as it can damage the immune system and intestinal flora. The impact of egg white peptides (EWPs) on dextran sulfate sodium‐induced young colitis mice models was investigated. Findings suggested that EWPs improved colitis symptoms and modulated inflammatory factors in mice. EWPs treatment could enhance the abundance ratio of Firmicutes to Bacteroidetes, the relative abundances of Lactobacillus, and the concentrations of short‐chain fatty acids (SCFAs). According to Pearson correlation analysis, Bacteroides was favorably connected with IL‐6 and negatively correlated with acetic acid and total SCFAs. In conclusion, EWPs relieved young mice's UC symptoms by inhibiting the progression of colitis, regulating the inflammation response, and improving the imbalance of intestinal flora. The current study also supports using EWPs as a practical dietary resource for ameliorating UC.

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“…46 Emerging evidence highlights the pivotal role of gut microbiome-derived SCFAs in several diseases, such as diabetes, colitis, allergy, and asthma. [47][48][49][50] Moreover, SCFAs play a significant role in enhancing regulatory T cells and promoting oral tolerance. These mechanisms are likely to contribute to the resolution of food allergies.…”

Section: Papermentioning

confidence: 99%

Lactobacillus rhamnosus Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism

Shi,

Dong,

Liu

et al. 2023

Food Funct.

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Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis

Abstract: The live Lactobacillus acidophilus (La) alleviated colitis by ameliorating intestinal barrier and suppressing inflammation. SCFAs modulated and enriched by La promoted the mitophagy/NLRP3 inflammasome pathway, which helped to improve gut functions.

Cited by 33 publications

References 46 publications

Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

Egg white peptides administration in enhancing pathological immune response and regulating intestinal bacteria abundance: A new strategy for relieving young mice colitis

Lactobacillus rhamnosus Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism

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