Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function

Yang, Zhandong; Ye, Simin; Xu, Zengmei; Su, Huihui; Tian, Xing; Han, Bo; Shen, Baochun; Liao, Qiongfeng; Xie, Zenghong; Hong, Yanjun

doi:10.1016/j.foodres.2021.110569

Cited by 37 publications

(29 citation statements)

References 40 publications

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“…Proteobacteria comprise many pathogenic genera and are believed to be a potential pro-inflammatory phylum ( 38 ). The positive association of some species with constipation was inhibited in constipated mice via the TY-S01 intervention, such as Ruminococcaceae , Clostridium-sensu-stricto-1 , Parasutterella , and Escherichia-Shigella ( 12 , 39 , 40 ). Furthermore, the populations of Lachnospiraceae , Bacteroidaceae , Desulfovibrio , and Eubacterium-brachy- group were heightened after TY-S01 treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Bacteroidetes promote the expression of gut-associated proteins to accelerate intestinal motility ( 42 ). And Desulfovibrio, Eubacterium-brachy- group have a positive effect on ameliorating constipation ( 12 , 43 ). Surprisingly, there were obvious associations of metabolic biomarkers with specific species in the intestine by correlation analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The research by Yang et al determined that dietary synbiotics ( Bifidobacterium animalis subsp. lactis , Lactobacillus rhamnosus , Lactobacillus acidophilus , and Lactobacillus plantarum participated in the composition) alleviated constipation via increasing the population of beneficial bacteria, stimulating the emancipation of gastrointestinal hormones and repressing the inflammatory response in mice ( 12 ). Not exclusively, another report verified that Bifidobacterium heightened the population of Lactobacillus but lowered the population of Odoribacter and Clostridium in the gut to attenuate constipation in mice, and illustrated interspecies differences ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

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Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice

Tang¹,

Wang²,

Jiang³

et al. 2022

Front. Nutr.

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Probiotics have received widespread attention as a healthy ingredient. The preventive effect of Bifidobacterium lactis TY-S01 on loperamide-induced constipation in mice was investigated in this study. TY-S01 accelerated the peristalsis of intestine, maintained the humidity of faeces, and prevented the destruction of gut barrier. TY-S01 also maintained the 5-HT, MTL and SP at normal levels in constipated mice. Simultaneously, TY-S01 up-regulated the mRNA expressions of 5-HT4R, SERT, and MUC-2, while down-regulated the mRNA expressions of pro-inflammatory genes remarkably. The levels of short-chain fatty acids in the feces of constipated mice were also increased because of the intervention with TY-S01. Moreover, TY-S01 prevented gut microbiological dysbiosis in constipated mice. Spearman’s correlation analysis revealed that there was an obvious association between metabolic biomarkers and gut microbiota. In summary, TY-S01 regulated gut microbiota and the production of intestinal metabolites to prevent loperamide-induced constipation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice

Tang¹,

Wang²,

Jiang³

et al. 2022

Front. Nutr.

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“…A recent report suggested that Alistipes could produce succinic acid, which helps to maintain intestinal homeostasis by accelerating cell differentiation, promoting tight junction assembly, and increasing the expression of proglucagon in intestinal L cells [ 38 ]. In addition, Faecalibaculum , a kind of lactic acid producer, is known to be strongly negatively related to inflammatory cytokines (IL-6 and TNF-α) [ 39 ]. Taken together, our results clearly elaborate that B. pseudolongum (Bp7 and Bp8) intervention regulates the intestinal microbiota structure, and its collective effects suppress intestinal inflammation.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of Colitis Mice via Modulating the Pparγ/STAT3 Pathway and Intestinal Microbiota

Guo

Mao

Cui

et al. 2022

Foods

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Colitis has become a major health concern worldwide. The objective of the present study was to determine the probiotic influence of different strains of B. pseudolongum (Bp7 and Bp8) on alleviating colitis and to explore its possible potential mechanisms. Our results displayed that Bp7 and Bp8 intervention effectively reduced dextran sodium sulfate (DSS)-caused body weight loss and the release of several pro-inflammatory factors (interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α)) and increased the activities of antioxidant enzymes (T-AOC, SOD, and GSH) and the concentrations of tight junction proteins (occludin, claudin-1, and ZO-1). Moreover, Bp7 and Bp8 intervention drastically down-regulated the expression of colonic MyD88, NF-κB, iNOS and COX2 and drastically elevated the expression of colonic STAT3, Nrf2, and PPARγ. Gas chromatography-mass spectrometry results revealed that the cecal levels of isobutyric, butyric, and isovaleric acids were drastically increased in colitis mice intervened with Bp7 and Bp8. Moreover, 16S rRNA sequencing revealed that Bp7 and Bp8 intervention modulated the intestinal microbiota structure, particularly by enhancing the proportion of Eubacterium coprostanoligenes group, Marvinbryantia, Enterorhabdus, Faecalibaculum, Coriobacteriaceae UCG 002, Alistipes, and Bifidobacterium, which are relevant to the levels of cecal isobutyric acid, butyric acid, isovaleric acid, and inflammatory cytokines. Collectively, these findings suggest that Bp7 and Bp8 intervention alleviates the intestinal barrier function, possibly by blocking the secretion of proinflammatory cytokines, maintaining the intestinal physical barrier integrity, activating the PPARγ/STAT3 pathway, and modulating intestinal microbiota composition. Our study also suggested that B. pseudolongum is a promising probiotic for colitis treatment.

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“…Low levels of fecal SCFAs have been observed in a mouse model of depression [140], while administration of dietary fiber increased SCFA formation by gut bacteria, which was linked to increased monoamine expression and reduced depressive-like behavior in mice [141,142]. While direct administration of SCFAs does not appear to affect the motilin levels [143], administration of a dietary symbiotic was associated with concurrent increases in the levels of motilin and gut SCFAs in an animal model of constipation, which correlated with improvements in bowel functioning [144]. These findings suggest that a significant relationship exists between certain dietary components and motilin secretion, which may merit further examination when examining dietary gut-brain axis relationships in depression.…”

Section: Dietmentioning

confidence: 97%

Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin

Rajkumar

2021

Life

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Recent research has identified the gut–brain axis as a key mechanistic pathway and potential therapeutic target in depression. In this paper, the potential role of gut hormones as potential treatments or predictors of response in depression is examined, with specific reference to the peptide hormone motilin. This possibility is explored through two methods: (1) a conceptual review of the possible links between motilin and depression, including evidence from animal and human research as well as clinical trials, based on a literature search of three scientific databases, and (2) an analysis of the relationship between a functional polymorphism (rs2281820) of the motilin (MLN) gene and cross-national variations in the prevalence of depression based on allele frequency data after correction for potential confounders. It was observed that (1) there are several plausible mechanisms, including interactions with diet, monoamine, and neuroendocrine pathways, to suggest that motilin may be relevant to the pathophysiology and treatment of depression, and (2) there was a significant correlation between rs2281820 allele frequencies and the prevalence of depression after correcting for multiple confounding factors. These results suggest that further evaluation of the utility of motilin and related gut peptides as markers of antidepressant response is required and that these molecular pathways represent potential future mechanisms for antidepressant drug development.

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Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function

Cited by 37 publications

References 40 publications

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice

Protective Effects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of Colitis Mice via Modulating the Pparγ/STAT3 Pathway and Intestinal Microbiota

Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin

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