Background: Psoriasis is an immune-mediated, chronic inflammatory disease of genetic basis, which affects mainly the skin, although it has systemic pathological effects. The most severe forms have been associated with several diseases that have similar pathogenic factors. Many studies showed that trace elements play vital role in some inflammatory responses such as psoriasis. The aim of current study was to estimate the levels of serum trace elements (zinc, copper and Cu/ Zn ratio) in psoriatic patients and evaluate the impact of these values on the severity and pathogenesis of psoriasis. Methods: In this case-control study, (50) patients with psoriasis were divided into three subgroups (mild, moderate and severe) and (50) healthy controls were examined. PASI score for each patient was calculated. Serum levels of Cu and Zn were measured by Flameless Atomic Absorption Spectrophotometer and Cu/ Zn ratio was calculated. Results: After measurements and comparisons between psoriatic patients and age-, and gender-, matched control group, results showed significant differences in copper and Cu/ Zn ratio among these groups, but no significant differences in serum zinc were showed. There was significant increase in serum copper and Cu/ Zn ratio (P value = 0.017 and 0.032 for copper and Cu/ Zn ratio, respectively) for psoriatic patients as compared with control group. Results also showed no significant differences in serum zinc between psoriatic patients and control group. No significant differences in the concentration of serum copper were observed between females and males of patients group, but highly significant increase of serum zinc in female as compared with males of psoriatic patients. Conclusion: increased serum copper may play a major role in
The study aimed to estimate the role of glucagon-like peptide-1 (GLP-1) and visfatin as a novel pro inflammatory marker in Rheumatoid Arthritis (RA ) according to the activity scores of disease to assess the possibility of introducing glucagon-like peptide-1 and visfatin in the diagnosis and monitoring of RA patients and to found the correlation of visfatin level with GLP-1 and AIP in patients prone to atherosclerosis ,fifty healthy individuals as control group (G1) and fifty rheumatoid arthritis (RA) patients (G2) were enrolled in this study with middle age ranged (30 – 40) years and BMI ≥24 kg/m2. ESR ,RF, lipid profile, CRP,insulin, visfatin and GLP-1were determined. Results in table (1) revealed highly significant increase in ESR,RF,TC,TG,LDL,VLDL and AIP level in rheumatoid arthritis (G2) comparing to (G1) while significant decrease noticed in (G2) group comparing to (G1). Results in table(2) showed highly significant increase in insulin ,CRP, visfatin and GLP-1 level Results in table(3) illustrated correlation relation data and results revealed highly significant ,were r=0.035 for GLP-1 with visfatin for (G1), and highly significant , r= -0.089 for (G2) as shown in figure(1-A) and(1-B), the result also highly significant were r= -0.183 for GLP-1 with CRP for control group and significant ,r= 0.043 for GLP-1 with CRP for RA group as shown in figure(2-A) and(2-B), and significant, r= -0.056 for GLP-1with AIP for G1 and no significant, were r= 0.042 for GLP-1 with AIP for G2 as shown in figure (3-A)and (3-B). conclusion that summarized from this study is glucagon-like peptide-1 and visfatin plays a role in RA pathogenesis that can be considered marker in RA . and may be used as a drug in future for RA patients.
The presented study aims to evaluate of the levels of serum Visfatin, in patients with chronic obstructive Pulmonary diseases in Babylon-Iraq , to find the correlation of Visfatin, with lipid profile in these patients and compared with apparently healthy as case -control study. The study included (50) patients as patients group diagnosed with COPD (G1) and ( 50)as apparently control group(G2) .The age of all studied groups ranged between (40-65)years and BMI with (18.8-24.4) Kg/m 2 .Serum was used in determination of FBS, lipid profile( Ch,TG,HDL-c,LDL-c and VLDL-c) , insulin , CRP and Visfatin , Whole blood was used for determination of HbA1C . The results revealed significant elevation in FBG and HbA1c levels were seen in patients groups when comparing to healthy control .The results indicates a significant elevation in TC, TG ,LDL-c and VLDL-c in G1 comparing to G2. Also , HDL-c significant decreased in G1 comparing to G 2 , Also ,the results showed significant increased in CRP levels in G1 , when comparing to G2, A non significant visfatin and insulin level in G1 when compared with G2(p value = 0.486) , . A non significant correlation was found in G1 between visfatin ,TC,TG, HDL-c and VLDL-c.The conclusion from this study indicate that G1 which HDL-c is low in this group has the highest value for FBS , HbA1c , TC ,TG,LDL and VLDL .Also, the study found non correlation between lipid profile parameters in G1
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