Assessment of serum zinc, copper and copper/zinc ratio in adult patients with psoriasis

Abstract

Background: Psoriasis is an immune-mediated, chronic inflammatory disease of genetic basis, which affects mainly the skin, although it has systemic pathological effects. The most severe forms have been associated with several diseases that have similar pathogenic factors. Many studies showed that trace elements play vital role in some inflammatory responses such as psoriasis. The aim of current study was to estimate the levels of serum trace elements (zinc, copper and Cu/ Zn ratio) in psoriatic patients and evaluate the impact of these values on the severity and pathogenesis of psoriasis. Methods: In this case-control study, (50) patients with psoriasis were divided into three subgroups (mild, moderate and severe) and (50) healthy controls were examined. PASI score for each patient was calculated. Serum levels of Cu and Zn were measured by Flameless Atomic Absorption Spectrophotometer and Cu/ Zn ratio was calculated. Results: After measurements and comparisons between psoriatic patients and age-, and gender-, matched control group, results showed significant differences in copper and Cu/ Zn ratio among these groups, but no significant differences in serum zinc were showed. There was significant increase in serum copper and Cu/ Zn ratio (P value = 0.017 and 0.032 for copper and Cu/ Zn ratio, respectively) for psoriatic patients as compared with control group. Results also showed no significant differences in serum zinc between psoriatic patients and control group. No significant differences in the concentration of serum copper were observed between females and males of patients group, but highly significant increase of serum zinc in female as compared with males of psoriatic patients. Conclusion: increased serum copper may play a major role in

Effect of CoQ10 Administration to Psoriatic Iraqi Patients on Biological Therapy Upon Severity Index (PASI) and Quality of Life Index (DLQI) Before and After Therapy.

“…2 Psoriasis vulgaris accounts for approximately 85% to 90% of all psoriasis patients. 3,4 The pathophysiology of psoriasis is complicated, and many processes involved are yet to be identified. The inflammatory response is influenced by a complicated interplay between genetic susceptibility and environmental factors.…”