Tea is one of the most ancient popular beverages and extensively used dietary supplement in the western world. Tea leaves are rich in polyphenols and also well known for its antioxidant properties. In addition, green tea extract contains several polyphenols with antioxidant compounds. The predominant effective antioxidant components are epigallocatechin 3-gallate and epicatechin 3-gallate (monomers). Tea polyphenols have an additional role to induce aroma and taste in beverages. Furthermore, tea polyphenols have multiple applications in food industry and biomedical applications. This chapter will summarise the origin of tea leaves and its beneficial account on antioxidant, food industry (meat products, plant products and fish products) and therapeutic applications against many diseases such as lowering of blood pressure, diabetes, Parkinson's disease and anticancer properties. Mainly tea polyphenols have potential to inhibit the cancer proliferation of skin, prostate, lung and breast cancer.
Nanomotors are the new generation drug delivery devices that find their major application in the pharmaceutical sector. This chapter highlights the basic aspects, mechanisms, and applications of nanomotors in antibacterial therapy, cancer therapy, nano-surgery, and imaging. Because of their higher penetration ability, rapid transportation, and controlled mobility, micro and nanomotors are referred as new generation targeted drug delivery devices. The detecting and sensing ability of nanomotors find potential applications in diagnostics and therapeutics. Bio-hybrid nanomotors are most attracting candidates for effective drug delivery. Bio-functionalized nanomotor can be used for detection and identification of tumor cells. Thus, nanomotors and micromotors can pave way for development of diagnostic and therapeutic tools for the future. Further development in these areas facilitate the discovery of lab-on-chip devices that can be used for super-fast screening and clinical diagnostic applications.
ABSTRACT:Recently, Heptapleurum stellatum is commonly known in India as Umbrella tree, has a wide range of medicinal uses. This study aimed to evaluate the phytoconstituents, antioxidant activities, total phenolic content and its compound characterization in leaves. Phytochemical analysis was indicated the presence of alkaloids, carbohydrates, steroids, saponins, glycosides, and terpenoids. The total phenolic content was measured by folinciocalteau assay. The total antioxidant capacity was estimated spectrometrically by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), ferric reducing antioxidant power (FRAP) and H2O2 assay. The methanol extracts exhibited maximum antioxidant activity. A high phenolic content of 0.357-2.004 GAE/mg and potent antioxidant activity (IC50 value=80 µg/mL) was observed in methanol leaf extract. High reducing ability in the FRAP assay (IC50 value=154.24 µg/mL) and H2O2 assay (IC50 value=110 µg/mL) was also observed in methanol leaf extract of H. stellatum. Bioactive compounds were screened using GC-MS analysis. The results suggest that H. stellatum has promising antioxidant activity and could serve as a potential source of natural antioxidants.
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