The objective of the present investigation was to formulate and evaluate microencapsulated Glibenclamide produced by the emulsion solvent evaporation method. Microparticles were prepared using Eudragit RLPO by emulsion solvent evaporation method and characterized for their micromeritic properties, encapsulation efficiency, particle size, drug loading, FTIR, DSC, SEM analysis. In vitro release studies were performed in phosphate buffer (pH 7.4). Stability studies were conducted as per ICH guidelines. The resulting microparticles obtained by solvent evaporation method were free flowing in nature. The mean particle size of microparticles ranges from 134.49 179.72 µm and encapsulation efficiency ranges from 92.30-98.32%. The infrared spectra and differential scanning calorimetry thermographs confirmed the stable character of Glibenclamide in the drug-loaded microparticles. Scanning electron microscopy revealed that the microparticles were spherical in nature. In vitro release studies revealed that the drug release was sustained up to 12 hrs. The release kinetics of Glibenclamide from optimized formulation followed zero-order and peppas mechanism. The mechanism of drug release from the microparticles was found to be non-Fickian type. Eudragit RLPO microparticles containing Glibenclamide could be prepared successfully by using an emulsion solvent evaporation technique, which will not only sustain the release of drug but also manage complicacy of the diabetes in a better manner.DOI: http://dx.doi.org/10.3329/icpj.v2i12.17016 International Current Pharmaceutical Journal, November 2013, 2(12): 196-201
Development of new excipients is time consuming, involves tedious procedures and is highly expensive. Instead, identification of new uses for the existing substances is relatively inexpensive and less time consuming. The intension of the present study was designed for isolation and characterization of mucilage from the pulp of Lagenaria siceraria and explores its use as pharmaceutical excipients. Various methods to isolate mucilage were tried and simple, economical and optimum method was developed. Physicochemical properties of Lagenaria siceraria such as appearance, odour, solubility, Bulk and Tapped Densities, Hausner's Ratio, swelling index, pH, compressibility and Angle of Repose were studied. The average yield of dried mucilage obtained from Lagenaria siceraria pulp mucilage was 20 g/kg. Bulk density was found to be 0.256 g/cm 3 and tapped density was 0.35 g/cm 3 , Carr's index was 19.1 %, Hausner ratio was 1.306 and angle of repose was found to be 20 0 .29". Phytochemical tests carried out on Lagenaria siceraria pulp mucilage confirmed the presence of vitamins, glycosides and carbohydrates. The FTIR spectrum of Lagenaria siceraria pulp mucilage showed N-H stretching, O-H stretching, C-H stretching, C=O stretching C=N stretching and C-C stretching at respective wave lengths. DSC thermogram of pulp powder shows sharp endothermic peak at 87.05°C and exothermic peak at 333.23°C. Scanning Electron Microscopy of Lagenaria siceraria pulp shows that they have irregular size and shapes. From the Study it is very clear that, Lagenaria siceraria pulp extract has wide range of applications and ensures as a promising excipient in various pharmaceutical formulations.
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