Formulation development and evaluation of Glibenclamide loaded Eudragit RLPO microparticles

Kumar, Balagani Pavan; Chandiran, Irisappan Sarath; Jayaveera, Κ. N.

doi:10.3329/icpj.v2i12.17016

Cited by 8 publications

(5 citation statements)

References 12 publications

(11 reference statements)

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“…Samples were analyzed in Cu Kα radiation with voltage of 40kv and a current of 40mA in 5-30° range on the 2θ scale. 19 In vitro drug release study…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

Ale,

Nainwal,

Butola

et al. 2023

Ind. J. Pharm. Edu. Res.

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Introduction: Diclofenac Sodium (DS), a Non-Steroidal Anti-Inflammatory Drug (NSAID) is widely used in inflammation and pain management. However, the drug has a short half-life of 1.2-2 hr therefore, frequent administration of DS is required. In this research paper Inter-Penetrating Network (IPN) microspheres of Diclofenac sodium were made using Isabgol husk mucilage and Polyvinyl Alcohol (PVA) to prolong the release of diclofenac sodium. Isabgol husk is widely explored as a natural, economical, biocompatible, and biodegradable polymer for the development of a modified-release drug delivery system. Materials and Methods: IPN microspheres were prepared using Isabgol husk mucilage and Polyvinyl alcohol by emulsion cross-linking method in the presence of DL glyceraldehyde as a cross-linker. Evaluation: Fourier Transform Infrared (FTIR) spectroscopy was performed to confirm the formation of an interpenetrating network. The chemical stability of the drug and its molecular dispersion in the IPN was validated by X-ray Diffraction (XRD) analysis. The prepared microspheres were evaluated for % yield, drug loading, entrapment efficiency, surface morphology, swelling index and in vitro drug release. Results: The percentage yield and drug entrapment efficiency of the formulations were found in between 66.33 to 95.345%, and 40.24 to 68.12% respectively. The SEM and light microscopy studies confirmed the formation of spherical IPN microspheres. The model kinetics of in vitro release data found Korsmeyer-Peppas as the best-fit model for drug release from IPN microspheres.

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“…Samples were analyzed in Cu Kα radiation with voltage of 40kv and a current of 40mA in 5-30° range on the 2θ scale. 19 In vitro drug release study…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

Ale,

Nainwal,

Butola

et al. 2023

Ind. J. Pharm. Edu. Res.

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“…The aliquotes (5 ml) were taken out at preset times and replaced by the fresh buffer. The test was run for a total duration of 15 h. The samples were filtered, diluted and analyzed spectrophotometrically at 232 nm [18,19].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Formulation of Mesalamine-Loaded Rectal Mucoadhesive Pellets for the Treatment of Inflammatory Bowel Disease Using 32full Factorial Design

VAJA

DETROJA

2022

Int J App Pharm

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Objective: The objective of the present work was to optimize a rectal suppository containing mucoadhesive pellets of Mesalamine to achieve local yet sustained release of Mesalamine for once-a-day administration for the therapy of Inflammatory Bowel Disease. Methods: Thus, the present work involves forming mucoadhesive pellets of mesalamine by extrusion spheronization, which were then loaded into a suppository to be administered rectally. The pellets were evaluated for mucoadhesion strength, swelling potential, morphology, particle size, drug release, drug loading and retention time. Results: The optimized batch of pellets using Eudragit RLPO as the release retardant, carrageenan as a mucoadhesive polymer and other excipients had a mucoadhesion strength of 0.143 N, a swelling index of 50.50 %, and 44 % and 75 % drug was released from them at the end of 6 and 15 h respectively. The pellets-loaded cocoa butter suppositories had a melting range of 35–37 °C, disintegrated within 8–9 min and had a hardness of 4–5 kg/cm3. A comparison of the in vitro drug release profile from the mucoadhesive pellets and the mucoadhesive pellets-loaded suppositories showed a closeness in the % cumulative drug release indicating that cocoa butter did not interfere in the release of the drug from the pellets. Conclusion: Mucoadhesive Pellets were successfully developed by extrusion spheronizer technique and incorporated into suppositories. In vitro study revealed a release profile that warranted a once-a-day regimen leading to a reduction in the requirement of the drug and hence the side effects.

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“…All samples were measured in the 2θ angle range between 5° and 60° 2.4.8. Differential scanning calorimetric (DSC) 16,17 DSC analysis of the samples was carried out on a Perkin-Elmer DSC7, USA. Samples (6.5-10 mg) were heated under nitrogen atmosphere on an aluminum pan at a heating rate of 10 °C/min over the temperature range of 5 and 300 °C.…”

Section: In Vitro Drug Release Study 12mentioning

confidence: 99%

Formulation and Development of Particulate Mucoadhesive Drug Delivery System of Venlafaxine Hydrochloride.

.¹,

.²,

Jagtap³

et al. 2018

JCPR

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The aim of this research was to formulate and evaluate Venlafaxine Hydrochloride mucoadhesive microsphere prepared using Sodium carboxy methylcellulose and sodium alginate combination. Venlafaxine hydrochloride having extensive hepatic first pass metabolism and low bioavailability problem, determined the need for the development of sustained release formulation. Venlafaxine Hydrochloride mucoadhesive microspheres were prepared by ionic gelation method. Mucoadhesive microspheres were prepared by using calcium chloride as cross linking agent. The venlafaxine hydrochloride mucoadhesive microsphere was characterized by particle size measurement, process yield, morphology of microsphere, drug entrapment efficiency, mucoadhesion test, differential scanning calorimetry, powder X-ray diffraction, Fourier transforms infrared (FTIR) study and in-vitro drug release. FTIR, XRD and DSC analyses apparently did not indicate any interaction of the drug with the polymers. However, the drug content, drug entrapment efficiency and morphology of the microsphere were found to be influenced by the method of preparation, composition of microsphere as well as exposure to the cross linking agent. The particle size was increase significantly by increasing polymer concentration. In vitro drug release study showed that drug release can be modified by varying drug to polymer ratio. The release rate was found to be decreased in accordance with the increase in the ratio of polymer used. The release profile of drug follows the zero order models indicated that the drug release from these microsphere followed sustain release pattern.

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Formulation development and evaluation of Glibenclamide loaded Eudragit RLPO microparticles

Cited by 8 publications

References 12 publications

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

Formulation and Characterization of Inter-Penetrating Network of Isabgol Husk Mucilage for Modified Release of Diclofenac Sodium

Formulation of Mesalamine-Loaded Rectal Mucoadhesive Pellets for the Treatment of Inflammatory Bowel Disease Using 32full Factorial Design

Formulation and Development of Particulate Mucoadhesive Drug Delivery System of Venlafaxine Hydrochloride.

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