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New solid and hollow monodispersed micron-sized organic-inorganic hybrid magnetic nan';lparticles have been recently prepared and characterized in our laboratory. The solid particles were formed by seeded polymerization of iron salts onto polystyrene monodispersed micron-sized (1-6 J.lID) particles. A further coating of these ferrite-coated particles with silica nanoparticles of significantly lower diameter (30-40 nm) was prepared by seeded polymerization of these particles with Si(OEt)4. The effect of the polystyrene surface composition on the ~ting of the polystyrene with ferrite and with silica is demonstrated. Hollow ferrite silica micron-sized particles were formed by burning off the polystyrene core of the former hybrid particles. Surface modification of these particles was performed by reacting these silica-coated particles with a variety of m-alcoholic reagents or m-alkylsilane compoWlds. The potential biomedical use of these ferrite-coated particles is also demonstrated and discussed.

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