Ferrite-Coated Nanoparticles: Synthesis and Biomedical Applications

Margel, Shlomo; Burdygin, I.; Gura, Sigalit; Bamnolker, Hanna; Nitzan, B.; Kedem, M.; Melamed, O. P.; Zuberi, Merav; Boguslavsky, Lior; Mandel, E.; Sheihet, Larisa; Tennenbaum, Tami; Bar-Toov, Beni

doi:10.3379/jmsjmag.22.s1_429

Cited by 18 publications

(30 citation statements)

References 8 publications

(5 reference statements)

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“…[1][2][3][4][5][6][7] Dispersion polymerization is a common method for preparing nonporous, uniform micrometer-sized particles in a single step. [8][9][10][11][12] However, the particles formed by this method possess a relatively small surface area, and their properties, for example, porosity, surface morphology, and functionality, are difficult to manipulate.…”

Section: Introductionmentioning

confidence: 99%

Synthesis by a single‐step swelling process and characterization of micrometer‐sized polychloromethylstyrene/poly(butyl methacrylate) hemispherical composite particles of narrow size distribution

Baruch-Sharon

Margel

2008

J of Applied Polymer Sci

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Polychloromethylstyrene (PCMS) micrometer-sized particles of narrow size distribution were prepared by the dispersion polymerization of chloromethylstyrene in a mixture of ethanol and dimethyl sulfoxide. Micrometer-sized PCMS/poly(butyl methacrylate) hemispherical composite particles of narrow size distribution were prepared by a single-step swelling process of the uniform PCMS template particles with emulsion droplets of butyl methacrylate (BMA) containing benzoyl peroxide, followed by the polymerization of BMA at 738C within the swollen template particles. The effects of various polymerization parameters, for example, BMA volume, initiator type and concentration, and toluene as the swelling solvent, on the properties (size and size distribution, morphology, polymerization yield, and composition) of the hemispherical composite particles were elucidated.

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Section: Introductionmentioning

confidence: 99%

Synthesis by a single‐step swelling process and characterization of micrometer‐sized polychloromethylstyrene/poly(butyl methacrylate) hemispherical composite particles of narrow size distribution

Baruch-Sharon

Margel

2008

J of Applied Polymer Sci

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“…17 Superparamagnetic iron oxide (IO) nanoparticles have a wide range of biomedical applications, such as magnetic resonance imaging contrast agents, drug delivery, specific cell labeling, cell tracking, diagnostics, and hyperthermia. [18][19][20][21][22] Previously, a unique type of uniform IO nanoparticles was prepared and characterized in our laboratory. 23,24 These IO nanoparticles were formed by controlled nucleation of IO onto gelatin, dissolved in an aqueous solution, and followed by stepwise growth of thin layers of IO films onto gelatin-IO nuclei.…”

Section: Introductionmentioning

confidence: 99%

Design of near-infrared fluorescent bioactive conjugated functional iron oxide nanoparticles for optical detection of colon cancer

Corem-Salkmon¹,

Perlstein²,

Margel³

2012

IJN

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Background: Colon cancer is one of the major causes of death in the Western world. Early detection significantly improves long-term survival for patients with the disease. Near-infrared (NIR) fluorescent nanoparticles hold great promise as contrast agents for tumor detection. NIR offers several advantages for bioimaging compared with fluorescence in the visible spectrum, ie, lower autofluorescence of biological tissues, lower absorbance, and consequently deeper penetration into biomatrices. Methods and results: NIR fluorescent iron oxide nanoparticles with a narrow size distribution were prepared by nucleation, followed by controlled growth of thin iron oxide films onto cyanine NIR dye conjugated gelatin-iron oxide nuclei. For functionalization, and in order to increase the NIR fluorescence intensity, the NIR fluorescent iron oxide nanoparticles obtained were coated with human serum albumin containing cyanine NIR dye. Leakage of the NIR dye from these nanoparticles into phosphate-buffered saline solution containing 4% albumin was not detected. The work presented here is a feasibility study to test the suitability of iron oxide-human serum albumin NIR fluorescent nanoparticles for optical detection of colon cancer. It demonstrates that encapsulation of NIR fluorescent dye within these nanoparticles significantly reduces photobleaching of the dye. Tumor-targeting ligands, peanut agglutinin and anticarcinoembryonic antigen antibodies (αCEA), were covalently conjugated with the NIR fluorescent iron oxidehuman serum albumin nanoparticles via a poly(ethylene glycol) spacer. Specific colon tumor detection was demonstrated in chicken embryo and mouse models for both nonconjugated and the peanut agglutinin-conjugated or αCEA-conjugated NIR fluorescent iron oxide-human serum albumin nanoparticles. Conclusion: Conjugation of peanut agglutinin or αCEA to the nanoparticles significantly increased the fluorescence intensity of the tagged colon tumor tissues relative to the nonconjugated nanoparticles.

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“…[1][2][3][4][5][6][7] Dispersion polymerization is the common method for preparing uniform nonporous micrometer-sized particles in a single step. [8][9][10][11] However, the particles formed by this method possess a relatively small surface area and their properties, such as porosity, surface morphology and functionality, can hardly be manipulated.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of air‐stable magnetic Fe composites microspheres of narrow size distribution

Shpaisman

Margel

2007

J of Applied Polymer Sci

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Air-stable Fe magnetic nanoparticles entrapped within carbon and porous crosslinked polystyrene microspheres of narrow size distribution were prepared by the following sequential steps: (1) Polystyrene/poly(divinyl benzene) and polystyrene/poly(styrene-divinyl benzene) uniform micrometer-sized composite particles were prepared by a single-step swelling of uniform polystyrene template microspheres dispersed in an aqueous continuous phase with emulsion droplets of dibutyl phthalate containing the monomers divinyl benzene and styrene and the initiator benzoyl peroxide. The monomers within the swollen polystyrene template microspheres were then polymerized by raising the temperature to 738C; (2) Porous poly (divinyl benzene) and poly(styrene-divinyl benzene) uniform crosslinked microspheres were prepared by dissolution of the polystyrene template part of the former composite particles; (3) Uniform magnetic poly(divinyl benzene)/Fe and poly(styrene-divinyl benzene)/Fe composite microspheres were prepared by entrapping Fe(CO) 5 within the porous crosslinked microspheres, by suction of the Fe complex into the dried porous particles, followed by decomposition of the encapsulated Fe(CO) 5 at 2008C in Ar atmosphere; (4) Uniform magnetic air-stable C/Fe composite microspheres were prepared similarly, apart from changing the decomposition temperature from 200 to 6008C.

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Ferrite-Coated Nanoparticles: Synthesis and Biomedical Applications

Cited by 18 publications

References 8 publications

Synthesis by a single‐step swelling process and characterization of micrometer‐sized polychloromethylstyrene/poly(butyl methacrylate) hemispherical composite particles of narrow size distribution

Synthesis by a single‐step swelling process and characterization of micrometer‐sized polychloromethylstyrene/poly(butyl methacrylate) hemispherical composite particles of narrow size distribution

Design of near-infrared fluorescent bioactive conjugated functional iron oxide nanoparticles for optical detection of colon cancer

Synthesis and characterization of air‐stable magnetic Fe composites microspheres of narrow size distribution

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