Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
A comparative analysis of the results of surgical treatment of 75 patients with toxic diffuse goiter and nodular goiter forms, including by means of endovideo-surgical equipment. The direct results of conservative therapy and its economic component were studied, the consequences of radioiodine treatment with the development of indications and contraindications to such treatment were estimated. Quantitative and qualitative assessment of major complications arising from the various surgical interventions on the thyroid gland and while the treatment by radioactive iodine was performed.
Сравнительный анализ различных методов диагностики многоузлового зоба определил приоритет прицельной тонкои-гольной биопсии и цитологического исследования каждого из узлов. Органосохраняющие резекции щитовидной железы оказались адекватными только при поражении одной доли коллоидным пролиферирующим зобом или фолликулярной опухолью, в том числе в рамках сочетанных форм. Предложенная модель выбора эндоскопической хирургической так-тики позволила получить лучшие косметические результаты, не жертвуя объемом операции при различных вариантах патологии щитовидной железы. Ключевые слова: заболевания щитовидной железы, хирургическое лечение.Comparative analysis of different methods of multinodular goiter diagnosis identified priority of fine-needle aspiration biopsy with subsequent cytologic examination of each node. Organ preserving thyroid resection appeared to be adequate only in case of unilobar colloid proliferating goiter or follicular tumor including combined lesions. Proposed model of choice of endoscopic surgical approach allowed receiving better cosmetic results not sacrificing extent of surgery for different types of thyroid pathology.
Phlegmon of a neck represents the serious illness which is characterized by development of the poured pyoinflammatory process in the cells spaces with fast distribution of purulent zatek that is caused by anatomic features. The clinical picture of a disease doesn’t allow to establish prevalence of pathological process in the preoperative period very often, and a large number of important anatomic formations don’t allow to sanify the center single-stages. The clinical supervision with option of treatment of the patient and a positive outcome is given in article.
According to a number of authors, the incidence of lymphorrhea after surgical treatment of breast cancer reaches 100%. In recent years, new methods of treating postoperative lymphorrhea have begun to appear, including the use of photodynamic therapy (PDT).Purpose of the study: to determine the possibility of using photodynamic therapy in the treatment of postoperative lymphorrhea and to evaluate its impact on the quality of life of patients.Material and methods. A prospective study involving 40 people was conducted. In 20 patients, photodynamic therapy was used in the treatment of postoperative lymphorrhea (main group), in 20 patients, punctures and pressure bandages were used (comparison group). Quality of life was assessed based on the data of the SF-36 questionnaire before the start of treatment, after 3 and 6 months. After 1 year, the condition of all patients was also assessed to identify signs of lymphostasis.Results. In the main group, in patients who underwent photodynamic therapy, lymphorrhea was completely stopped by the end of the third week. In patients from the comparison group at the same time, the volume of daily lymphorrhea was (41.4 ± 0.3) ml. A statistically significant difference was found between the indicators of the physical component of health in patients of the two groups 3 months after the start of treatment: role functioning associated with the physical component, pain intensity, general health and vitality. At the same time, the use of photodynamic therapy did not increase the risk of developing lymphostasis of the upper limb.Conclusion. The study showed that the use of photodynamic therapy in the treatment of postoperative lymphorrhea can reduce the amount of lymph loss, reduce the time of outpatient treatment, and also improve the quality of life of patients, while not increasing the risk of developing lymphostasis of the upper limb.
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