The teeth of one child of 22 monozygotic twins were treated twice yearly with a 1-percent F–– (from SnF2) solution over a period of 9 years. When the children were 16 years old, the result was that the treated children had 37% fewer lesions than the controls. For the proximal surfaces, the reduction was 55%; for the pits and fissures, 20%; and for the free smooth surfaces, 61%. Five years after the last application, 18 pairs were examined once more. In three pairs, the controls had received full dentures. In the remaining 15 pairs, the treated children had 37% fewer cavities in the proximal surfaces; 8% fewer in the pits and fissures; and 45% fewer in the free smooth surfaces.
If it is true that small children chronically swallow toothpaste while brushing their teeth, the possibility exists that the use of a fluoride toothpaste during infancy might result in the ingestion of sufficient F to cause mottling in their permanent teeth. In order to test this hypothesis, the infant siblings of children participating in the clinical trial of a dentifrice containing 2% sodium monofluorophosphate were examined 6–8 years afterwards, following the eruption of their permanent teeth. No hypoplasia or mottling were found which might be attributed to the ingestion of undesirable amounts of monofluorophosphate toothpaste.
The influence of localization, posteruptive age and ethane-1-hydroxy-1.1 diphosphonate (EHDP) on artificial caries and its remineralization have been studied in human premolars. The depth of the lesions did not depend on the posteruptive age of the teeth, but on the localization on the teeth, presumably as a result of differences in morphological structure. At 30 μm from the surface of the enamel, an indication for a higher birefringence exists at a posteruptive age of 1 year than later on, suggesting a significantly higher de-mineralization which can be more fully remineralized, leading, in turn, to a lower birefringence. EHDP seems to stimulate, rather than to inhibit remineralization of artificial caries lesions in premolars with a posteruptive age of 1–5 years.
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