Background:Catestatin is emerging as a novel regulator of cardiovascular/metabolic functions. Results: We discovered a common amino acid substitution variant of catestatin that caused profound changes in plasma catecholamines, glucose, and lipid levels. Conclusion: Naturally occurring variants of catestatin peptide seem to alter the risk for metabolic syndrome. Significance: These findings provide new insights into the mechanism of metabolic diseases in humans.

A B S T R A C TBackground: Mortality in acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) approaches 70 − 80%, regardless of the type of pharmacological treatment. Early revascularisation improves survival in AMI with CS. Our aim is to assess the predictors of mid-term outcome after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) and CS.Methods: Forty-one patients who underwent primary or rescue PCI for CS were analysed comparing their baseline, angiographic, PCI data, 30-day and 1-year survival.Results: There were no significant differences between survivors and non-survivors in baseline characters, except for more number of transfer admissions (P = 0.0005), and cardiopulmonary resuscitations (P = 0.015) in the later group. The mean time between myocardial infarction (MI) onset to shock and MI onset to revascularisation were 12.8 ± 12.9 hours and 17.0 ± 16.8 hours, respectively. Patients with better pre-procedure thrombolysis in myocardial infarction (TIMI) flow in the infarctrelated artery (IRA) had better survival (P = 0.0005). Successful PCI was achieved in 48.8% of patients. The 30-day mortality was 56.1% and all were prior to hospital discharge. Patients with successful PCI had better short-term survival in comparison with patients with failed PCI (80% vs 9.6%). Eighteen patients who survived at 30 days were followed up for 12-72 months (mean 28.5 ± 5.4 months). Fifteen patients survived at 1 year after PCI and all were in good functional status. Conclusion:Mortality remains high even with PCI. Achieving IRA patency with TIMI 3 flow is the main determinant of survival. Survival and functional status are good in patients who are discharged from hospital.

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Background: Polycystic ovarian syndrome is a common female endocrine disorder affecting 4 – 18% of women in their reproductive age. It is common in adolescent girls. Polycystic Ovarian Syndrome affects throughout the life and produce gynaecological and metabolic health problems. The aim of this study to create the awareness about the polycystic ovarian syndrome to the adolescent girls.Methods: A Quantitative approach with pre- experimental design was used to study the effectiveness of STP on Poly Cystic Ovarian Syndrome. Ninety-four adolescent girls aged between 15 – 18 years were conveniently selected. Data was collected by using Structured Knowledge questionnaire.Results: The mean post-test knowledge score (22.55± 3.57) was higher than that of mean pre-test mean knowledge score (11.13± 3.32) and the mean difference was11.42. The ‘t’ calculated value was 23.45 which is higher than the tabulated value of 1.98 (df 93 at p< 0.05). Therefore, research hypothesis was accepted. So, it can be interpreting that structured teaching programme is effective in improving the knowledge of adolescent girls.Conclusions: The findings of the study revealed that STP was effective in enhancing the knowledge of adolescent girls on PCOS. Hence the study concluded that structured teaching programme had a great potentiality to increase the awareness on PCOS.

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Background: Mothers and new-borns are vulnerable to illness and deaths during the postnatal period. Care during postnatal period is the important part of maternal health care as the serious and life-threatening complications can occur in postnatal period.Methods: A Quantitative approach with pre- experimental design was used to study the effectiveness of STP on postnatal care. Sixty postnatal mothers were selected from tertiary care hospital. The Purposive sampling techniques was used to select the study subjects. Data was collected by using Structured Knowledge questionnaire.Results: The results show that the overall mean pre-test knowledge score of postnatal mothers was 19.8±2.98 and mean post-test knowledge score of postnatal mothers was 26.28±1.89 and the mean difference was 6.48. This revealed that the STP was an effective method in improving mother’s knowledge on postnatal care. There was no significant association found between pre-test knowledge score with their demographic variables except occupation.Conclusions: The findings of the study revealed that STP was effective in enhancing the knowledge of postnatal mothers on postnatal care.

Pregnancy-induced hypertension is a high-risk affecting almost all the vessels, particularly those of uterus, kidney, placental bed and brain result in the symptoms called Vascular Symptoms. Thus, it, directly and indirectly, have an effect on the physical and psychological QOL of pregnant women. The aim of this study was to assess the effect of Vascular Symptom Management Package (VSMP) on the Quality of Life (QOL) of pregnant women with PIH. A quantitative approach with the true experimental design was adopted. One hundred twenty women with PIH were selected for study by using a purposive sampling technique. Subjects were randomly assigned to an experimental and control group by using Sequentially Numbered, Opaque Sealed Envelops (SNOSE) (60 in Experimental group & 60 in Control group). The data analyzed by using descriptive and inferential statistics.  Paired 't' test used to compare the pre-test and post-test QOL scores within the group. The inferential statistics results revealed that the post-test QOL score is decreased in the control group and increased in the experimental group significantly. Independent sample ‘t’ test used to compare the pre and post-test QOL scores between experimental and control groups. The mean post-QOL score of the experimental group was higher than that of the mean post QOL score of the control group. This shows a significant increase in the QOL score in the experimental group. Hence it can be interpreted that VSMP is effective in improving the QOL. PIH is a life-threatening condition. The findings of this study show the effectiveness of VSMP improves the QOL. So VSMP is a nurse-led intervention that can be implemented to effectively reduce the vascular symptoms and improve the QOL of pregnant women with PIH.

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