Background:Catestatin is emerging as a novel regulator of cardiovascular/metabolic functions. Results: We discovered a common amino acid substitution variant of catestatin that caused profound changes in plasma catecholamines, glucose, and lipid levels. Conclusion: Naturally occurring variants of catestatin peptide seem to alter the risk for metabolic syndrome. Significance: These findings provide new insights into the mechanism of metabolic diseases in humans.

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A B S T R A C TBackground: Mortality in acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) approaches 70 − 80%, regardless of the type of pharmacological treatment. Early revascularisation improves survival in AMI with CS. Our aim is to assess the predictors of mid-term outcome after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) and CS.Methods: Forty-one patients who underwent primary or rescue PCI for CS were analysed comparing their baseline, angiographic, PCI data, 30-day and 1-year survival.Results: There were no significant differences between survivors and non-survivors in baseline characters, except for more number of transfer admissions (P = 0.0005), and cardiopulmonary resuscitations (P = 0.015) in the later group. The mean time between myocardial infarction (MI) onset to shock and MI onset to revascularisation were 12.8 ± 12.9 hours and 17.0 ± 16.8 hours, respectively. Patients with better pre-procedure thrombolysis in myocardial infarction (TIMI) flow in the infarctrelated artery (IRA) had better survival (P = 0.0005). Successful PCI was achieved in 48.8% of patients. The 30-day mortality was 56.1% and all were prior to hospital discharge. Patients with successful PCI had better short-term survival in comparison with patients with failed PCI (80% vs 9.6%). Eighteen patients who survived at 30 days were followed up for 12-72 months (mean 28.5 ± 5.4 months). Fifteen patients survived at 1 year after PCI and all were in good functional status. Conclusion:Mortality remains high even with PCI. Achieving IRA patency with TIMI 3 flow is the main determinant of survival. Survival and functional status are good in patients who are discharged from hospital.

Background: Polycystic ovarian syndrome is a common female endocrine disorder affecting 4 – 18% of women in their reproductive age. It is common in adolescent girls. Polycystic Ovarian Syndrome affects throughout the life and produce gynaecological and metabolic health problems. The aim of this study to create the awareness about the polycystic ovarian syndrome to the adolescent girls.Methods: A Quantitative approach with pre- experimental design was used to study the effectiveness of STP on Poly Cystic Ovarian Syndrome. Ninety-four adolescent girls aged between 15 – 18 years were conveniently selected. Data was collected by using Structured Knowledge questionnaire.Results: The mean post-test knowledge score (22.55± 3.57) was higher than that of mean pre-test mean knowledge score (11.13± 3.32) and the mean difference was11.42. The ‘t’ calculated value was 23.45 which is higher than the tabulated value of 1.98 (df 93 at p< 0.05). Therefore, research hypothesis was accepted. So, it can be interpreting that structured teaching programme is effective in improving the knowledge of adolescent girls.Conclusions: The findings of the study revealed that STP was effective in enhancing the knowledge of adolescent girls on PCOS. Hence the study concluded that structured teaching programme had a great potentiality to increase the awareness on PCOS.